文献类型： 外文期刊
作者： Yin, Wenzhu 1 ; Deng, Bihua 1 ; Xu, Zeyu 2 ; Wang, Haiyan 1 ; Ma, Fang 1 ; Zhou, Mingxu 1 ; Lu, Yu 1 ; Zhang, Jinqiu 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Natl Res Ctr Engn & Technol Vet Biol, Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base,Minist Sci & Technol,I, Nanjing 210014, Peoples R China
2.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China
关键词： adjuvant; imiquimod; cholesterol; liposolubility; foot-and-mouth disease
期刊名称：ACS INFECTIOUS DISEASES （ 影响因子：5.3； 五年影响因子：5.1 ）
ISSN： 2373-8227
年卷期： 2023 年 9 卷 2 期
页码：
收录情况： SCI
摘要： Adjuvants are essential for the induction of robust immune responses against vaccine antigens. Small-molecule TLR7 agonists hold high potential for this purpose. In this communication, imiquimod (IMQ) bearing a cholesterol lipid moiety derivative, IMQ-Chol, was designed and synthesized as a vaccine adjuvant, which could release parent IMQ molecules in aqueous conditions via amide bond hydrolysis. We performed a series of immunological evaluations by cooperating with the inactivated foot-and-mouth disease virus (FMDV). All of the results confirmed that IMQ-Chol could stimulate the body for a prolonged time to produce strong humoral and cellular immunity with a balanced Th1/Th2 immune response through a TLR7-related MAPK pathway. In addition, the results of the proof-of-concept vaccine indicated IMQ-Chol had a good effect on preventing and treating FMD in pigs.
- 相关文献
作者其他论文 更多>>
-
Staphylococcus aureus Conquers Host by Hijacking Mitochondria via PFKFB3 in Epithelial Cells
作者：Gao, Xing;Wu, Binfeng;Liu, Laizhen;Xu, Yuanyuan;Miao, Jinfeng;Feng, Shiyuan;Zhang, Jinqiu;Zhang, Jinqiu
关键词：glycolysis; SIRT3-HIF1 alpha; mitophagy; PFKFB3; Staphylococcus aureus
-
A Novel 10-Base Pair Deletion in the First Exon of GmHY2a Promotes Hypocotyl Elongation, Induces Early Maturation, and Impairs Photosynthetic Performance in Soybean
作者：Zhu, Xiaobin;Wang, Haiyan;Li, Yuzhuo;Wang, Feifei;Gao, Yi;Zhong, Weiyu;Zhao, Yujing;Xia, Zhengjun;Zhu, Xiaobin;Rao, Demin;Qiu, Hongmei;Zhang, Wei;Wu, Shihao;Chen, Xin
关键词：soybean; Gmeny; phytochromobilin; hypocotyl elongation; photosynthesis; GA signaling; maturity
-
Exploiting bacterial-origin immunostimulants for improved vaccination and immunotherapy: current insights and future directions
作者：Wang, Guangyu;Wang, Yongkang;Ma, Fang;Ma, Fang;Ma, Fang
关键词：Bacterial-origin immunostimulants; Vaccines adjuvants; PRR agonist; Innate immunity; Immunotherapy
-
Alginate di-aldehyde-modified metal-organic framework nanocarriers as delivery platform and adjuvant in inactivated pseudorabies vaccination
作者：Yin, Wenzhu;Chang, Chen;Zhao, Yanhong;Wang, Haiyan;Zhang, Jinqiu;Ma, Fang;Zuo, Xiaoxin;Tang, Bo;Lu, Yu;Yin, Wenzhu;Xu, Zeyu;Tang, Bo;Yin, Wenzhu;Lu, Yu
关键词：
-
Cistanche deserticola polysaccharide- functionalized dendritic fibrous nano-silica- based adjuvant for H 9 N 2 oral vaccine enhance systemic and mucosal immunity in chickens
作者：He, Jin;Lu, Xuanqi;Mao, Ningning;Zhu, Tianyu;Yu, Lin;Yu, Yaming;Peng, Song;Deng, Xiangwen;Hu, Bing;Wang, Deyun;Lu, Yu;Jiang, Wenming
关键词：Oral vaccine; Dendritic fibrous nano-silica; Adjuvant; Mucosal and systemic immunity; cetyltrimethylammonium bromide (CTAB); triethanolamine (TEA); sodium salicylate (Nasal); tetraethoxysilane (TEOS); 3-aminopropyltriethoxysilane (APTES); 1-Ethyl-3-(3-dimethylaminopropyl); carbodiimide(EDC & sdot;HOL); N-Hydroxy succinimide (NHS); Lipopolysaccharide (LPS); phytohaemagglutinin (PHA); Cistanche deserticola polysaccharide (CDP)
-
Thermostable vacuum foam dried Newcastle disease vaccine: Process optimization and pilot-scale study
作者：Lyu, Fang;Zhao, Yan-hong;Zuo, Xiao-xin;Deng, Bi-hua;Zhou, Ming-xu;Hou, Jibo;Jiao, Jia-jie;Zeng, Min-qian;Jie, Hong-ying;Lu, Yu;Lyu, Fang;Nyide, Babalwa;Khoza, Thandeka;Olaniran, Ademola;Lyu, Fang;Deng, Bi-hua;Zhou, Ming-xu;Lu, Yu;Lyu, Fang;Zhao, Yan-hong;Deng, Bi-hua;Jiao, Jia-jie;Zeng, Min-qian;Lu, Yu;Zuo, Xiao-xin;Lu, Yu
关键词：Vacuum foam drying; Process upscaling; NDV vaccine; Thermostability
-
Matrine Ameliorates DSS-Induced Colitis by Suppressing Inflammation, Modulating Oxidative Stress and Remodeling the Gut Microbiota
作者：Mao, Ningning;Yu, Yaming;He, Jin;Yang, Yang;Liu, Zhenguang;Wang, Deyun;Mao, Ningning;Yu, Yaming;He, Jin;Yang, Yang;Liu, Zhenguang;Wang, Deyun;Lu, Yu
关键词：DSS; matrine; ulcerative colitis; Treg/Th17; gut microbiota
