文献类型： 外文期刊
作者： Yin, Wenzhu 1 ; Deng, Bihua 1 ; Xu, Zeyu 2 ; Wang, Haiyan 1 ; Ma, Fang 1 ; Zhou, Mingxu 1 ; Lu, Yu 1 ; Zhang, Jinqiu 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Natl Res Ctr Engn & Technol Vet Biol, Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base,Minist Sci & Technol,I, Nanjing 210014, Peoples R China
2.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China
关键词： adjuvant; imiquimod; cholesterol; liposolubility; foot-and-mouth disease
期刊名称：ACS INFECTIOUS DISEASES （ 影响因子：5.3； 五年影响因子：5.1 ）
ISSN： 2373-8227
年卷期： 2023 年 9 卷 2 期
页码：
收录情况： SCI
摘要： Adjuvants are essential for the induction of robust immune responses against vaccine antigens. Small-molecule TLR7 agonists hold high potential for this purpose. In this communication, imiquimod (IMQ) bearing a cholesterol lipid moiety derivative, IMQ-Chol, was designed and synthesized as a vaccine adjuvant, which could release parent IMQ molecules in aqueous conditions via amide bond hydrolysis. We performed a series of immunological evaluations by cooperating with the inactivated foot-and-mouth disease virus (FMDV). All of the results confirmed that IMQ-Chol could stimulate the body for a prolonged time to produce strong humoral and cellular immunity with a balanced Th1/Th2 immune response through a TLR7-related MAPK pathway. In addition, the results of the proof-of-concept vaccine indicated IMQ-Chol had a good effect on preventing and treating FMD in pigs.
- 相关文献
作者其他论文 更多>>
-
Functional Genomics: From Soybean to Legume
作者：Zhou, Can;Wang, Haiyan;Qi, Zhaoming;Zhou, Can;Wang, Haiyan;Zhu, Xiaobin;Xia, Zhengjun;Li, Yuqiu;Zhang, Bo;Tadege, Million;Wu, Shihao
关键词：legume; T2T; genome; pangenome; functional genomics; soybean
-
Lipopeptide biosurfactants of Pseudomonas fragi showed intraspecific specificity to their biological traits
作者：Wang, Guangyu;Wang, Yongkang;Chen, Yuping;Ma, Fang
关键词：Pseudomonas; Biosurfactant; Biological traits; Intraspecific specificity
-
Enhanced Immunogenicity of Chicken H9N2 Influenza Inactivated Vaccine Through a Novel Dual-Targeting Fusion Protein Strategy
作者：Xu, Hai;Feng, Yaming;Xu, Hai;Deng, Bihua;Zhu, Yalu;Qi, Qiurong;Feng, Yaming;Deng, Bihua;Lu, Yu;Wu, Erzhong
关键词：dual targeting; avian influenza; dendritic cell; envelope virus
-
Nano-adjuvant based on lipo-imiquimod self-assembly for enhanced foot-and-mouth disease virus vaccine immune responses via intradermal immunization
作者：Yin, Wenzhu;Ma, Fang;Deng, Bihua;Zhao, Yanhong;Zuo, Xiaoxin;Wang, Haiyan;Lu, Yu;Xu, Zeyu;Zhao, Yanhong;Lu, Yu;Yin, Wenzhu;Deng, Bihua
关键词：Imiquimod; Lipidation; Self-assembly; Nano-adjuvant; Intradermal immunity; Foot-and-mouth vaccine
-
Immunogenicity of a novel HMT13 adjuvant-based inactivated vaccine against Avian pathogenic Escherichia coli serogroups O36, O78, and O109
作者：Jia, Chaoying;Wang, Zesong;Liu, Qingyun;Wang, Xiangru;Jia, Chaoying;Wang, Zesong;Liu, Qingyun;Wang, Xiangru;Fu, Jiyang;Li, Zugang;Yu, Jiangxu;Liu, Qingyun;Wang, Xiangru;Zhang, Jinqiu
关键词：Avian colibacillosis; APEC; Inactivated vaccine; HMT 13; Adjuvant
-
The aprD-mutated strain modulates the development of Pseudomonas fragi population but has limited effects on the spoilage profiles of native residents
作者：Wu, Yajie;Tan, Song;Niu, Ajuan;Chen, Yuping;Liu, Yuxin;Qiu, Weifen;Wang, Guangyu;Ma, Fang
关键词：Pseudomonas fragi; Chilled chicken; Spoilage; Microbial community
-
YiMu-QingGong san alleviates lipopolysaccharide-induced endometritis in mice via inhibiting inflammation and oxidative stress through regulating macrophage polarization
作者：Yu, Yaming;Mao, Ningning;Yu, Lin;Lin, Fangzhu;Shi, Xiaofeng;Lu, Xuanqi;Yang, Yang;Wang, Deyun;Yu, Yaming;Mao, Ningning;Yu, Lin;Lin, Fangzhu;Shi, Xiaofeng;Lu, Xuanqi;Yang, Yang;Wang, Deyun;Lu, Yu
关键词：Macrophage polarization; Inflammation; Endometritis; NF-kappa B; Fibrosis; Uterine barrier
