文献类型： 外文期刊
作者： Guo, Lichun 1 ; Xi, Bingwen 1 ; Lu, Liushen 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 214122, Jiangsu, Peoples R China
2.Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China
关键词： Co-cultivation; Microorganism; Natural products; Microbial interactions; Microbial consortia
期刊名称：BIORESOURCE TECHNOLOGY （ 影响因子：9.7； 五年影响因子：9.4 ）
ISSN： 0960-8524
年卷期： 2024 年 406 卷
页码：
收录情况： SCI
摘要： Increasing evidence shows that microbial synthesis plays an important role in producing high value-added products. However, microbial monoculture generally hampers metabolites production and limits scalability due to the increased metabolic burden on the host strain. In contrast, co-culture is a more flexible approach to improve the environmental adaptability and reduce the overall metabolic burden. The well-defined co-culturing microbial consortia can tap their metabolic potential to obtain yet-to-be discovered and pre-existing metabolites. This review focuses on the use of a co-culture strategy and its underlying mechanisms to enhance the production of products. Notably, the significance of comprehending the microbial interactions, diverse communication modes, genetic information, and modular co-culture involved in co-culture systems were highlighted. Furthermore, it addresses the current challenges and outlines potential future directions for microbial co-culture. This review provides better understanding the diversity and complexity of the interesting interaction and communication to advance the development of co-culture techniques.
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