Polysaccharides from Dendrobium officinale improve obesity-induced insulin resistance through the gut microbiota and the SOCS3-mediated insulin receptor substrate-1 signaling pathway
文献类型： 外文期刊
作者： Jiang, Wei 1 ; Tan, Jin 1 ; Zhang, Jiacheng 3 ; Deng, Xin 1 ; He, Xinyue 1 ; Zhang, Jin 4 ; Liu, Tong 5 ; Sun, Rong 1 ; Sun, Mengxun 1 ; Chen, Kuo 3 ; Xu, Tingjia 1 ; Yan, Yuling 1 ; Moazzami, Ali 6 ; Wu, E-Jiao 7 ; Zhan, Jiasui 9 ; Hu, Binhong 1 ;
作者机构： 1.Chengdu Normal Univ, Coll Chem & Life Sci, Chengdu, Peoples R China
2.Chengdu Normal Univ, Sichuan Prov key Lab Dev & Utilizat Characterist H, Chengdu, Peoples R China
3.Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China
4.Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS USA
5.Swedish Univ Agr Sci, Dept Forest Ecol & Management, Uppsala, Sweden
6.Swedish Univ Agr Sci, Dept Mol Sci, Uppsala BioCtr, Uppsala, Sweden
7.Jiangsu Acad Agr Sci, Inst Pomol, Nanjing, Peoples R China
8.Jiangsu Key Lab Hort Crop Genet Improvement, Nanjing, Peoples R China
9.Swedish Univ Agr Sci, Dept Forest Mycol & Plant Pathol, Uppsala, Sweden
10.Chengdu Normal Univ, Coll Chem & Life Sci, Chengdu, Sichuan, Peoples R China
关键词： Dendrobium officinale polysaccharides; obesity; insulin resistance; SD rats
期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：4.1； 五年影响因子：4.2 ）
ISSN： 0022-5142
年卷期： 2024 年 104 卷 6 期
页码：
收录情况： SCI
摘要： BACKGROUND: Obesity induces insulin resistance and chronic inflammation, impacting human health. The relationship between obesity, gut microbiota, and regulatory mechanisms has been studied extensively. Dendrobium officinale polysaccharide (DOP), a traditional Chinese herbal medicine, potentially reduces insulin resistance. However, the mechanism through which DOP affects gut microbiota and alleviates obesity-induced insulin resistance in rats requires further investigation.RESULTS: The current study aimed to assess the impact of DOP on gut microbiota and insulin resistance in rats on a high-fat diet. The results revealed that DOP effectively reduced blood lipids, glucose disorders, oxidative stress, and inflammatory infiltration in the liver of obese Sprague Dawley rats. This was achieved by downregulating SOCS3 expression and upregulating insulin receptor substrate-1 (IRS-1) by regulating the JAK/STAT/SOCS3 signaling pathway. Notably, DOP intervention enhanced the abundance of beneficial gut microbiota and reduced harmful microbiota. Correlation analysis demonstrated significant associations among intestinal microbiota, SOCS3-mediated IRS-1 expression, and inflammatory factors.CONCLUSION: Dendrobium officinale polysaccharide regulated the gut microbiota, enhanced IRS-1 expression, and mitigated liver injury and insulin resistance due to a high-fat diet. These findings depict the potential anti-insulin resistance properties of DOP and offer further evidence for addressing obesity and its complications.(c) 2023 Society of Chemical Industry.
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