Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets
文献类型: 外文期刊
作者: Xiang, Xin-Dong 1 ; Deng, Zhang-Chao 1 ; Wang, You-Wei 2 ; Sun, Hua 1 ; Wang, Li 3 ; Han, Yan-Ming 5 ; Wu, Yuan-Yuan 1 ;
作者机构: 1.Huazhong Agr Univ, Coll Anim Sci & Technol, Hubei Hongshan Lab, Wuhan 430070, Peoples R China
2.Hubei Univ Med, Sch Basic Med Sci, Hubei Key Lab Embryon Stem Cell Res, Shiyan 442000, Peoples R China
3.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou 510640, Peoples R China
4.Key Lab Anim Nutr & Feed Sci South China, Minist Agr, Guangzhou 510640, Peoples R China
5.Trouw Nutr, NL-773811 Amersfoort, Netherlands
6.Guangzhou Liuhe Feed Co Ltd, Guangzhou 511400, Peoples R China
7.Key Lab Feed & Livestock & Poultry Prod Qual & Sa, Minist Agr, Chengdu 610110, Peoples R China
关键词: weanling pigs; acidifiers; performance; redox status; immunity; gut microbiota
期刊名称:ANTIOXIDANTS ( 影响因子:6.313; 五年影响因子:6.649 )
ISSN:
年卷期: 2021 年 10 卷 11 期
页码:
收录情况: SCI
摘要: The objective of this study is to evaluate the effects of organic acids on piglet growth performance and health status. A total of 360 weanling pigs (5.3 & PLUSMN; 0.6 kg) were randomly allotted to 3 treatment groups with 12 replicates of 10 pigs/pen. Piglets were fed the same basal diet and given either water (control) or water plus 2.0 L/Ton organic acid (OA) blends, such as OA1 or OA2, respectively, for 7 weeks. Compared to the control, OA1 and OA2 improved growth performance and/or reduced the piglets' diarrhea rate during the various periods and improved small intestinal morphology at days 14 and/or 49. OA1 and OA2 also increased serum CAT and SOD activities and/or T-AOC and, as expected, decreased MDA concentration. Moreover, at day 14 and/or day 49, OA1 and OA2 increased the jejunal mRNA levels of host defense peptides (PBD1, PBD2, NPG1, and NPG3) and tight junction genes (claudin-1) and decreased that of cytokines (IL-1 beta and IL-2). Additionally, the two acidifiers regulated the abundance of several cecum bacterial genera, including Blautia, Bulleidia, Coprococcus, Dorea, Eubacterium, Subdoligranulum, and YRC2. In conclusion, both of the organic acid blends improved piglet growth performance and health status, potentially by regulating intestinal redox homeostasis, immunity, and microflora.
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