Enhanced biodegradation of sulfamethazine in swine manure composting: Pathway elucidation, mechanism insights, and optimization of a novel Bacillus sp. strain
文献类型： 外文期刊
作者： Lin, Xiaojun 1 ; Li, Jingtong 6 ; Chen, Chunyan 5 ; Luo, Zifeng 1 ; Tu, Hongxing 1 ; Pang, Yuwan 4 ; Wang, Xiujuan 1 ; Cai, Qianyi 1 ; Wei, Zebin 3 ; Huang, Jianfeng 4 ; Zeng, Jingwen 1 ; Qiu, Jinrong 1 ;
作者机构： 1.South China Inst Environm Sci MEE, Guangzhou 510655, Guangdong, Peoples R China
2.Minist Ecol & Environm, Key Lab Water Environm Simulat & Pollut Control, Guangzhou 510655, Peoples R China
3.South China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R China
4.Guangdong Acad Agr Sci, Inst Agr Resources & Environm, Guangzhou 510640, Peoples R China
5.Jinan Univ, Guangzhou 511443, Peoples R China
6.Yangtze Univ, Coll Agr, Jingzhou 434025, Hubei, Peoples R China
关键词： Swine manure compost; Sulfamethazine (SMZ); High degradation strain; Optimize degradation conditions; Biodegradation pathway
期刊名称：INTERNATIONAL BIODETERIORATION & BIODEGRADATION （ 影响因子：4.1； 五年影响因子：4.3 ）
ISSN： 0964-8305
年卷期： 2025 年 203 卷
页码：
收录情况： SCI
摘要： Sulfamethazine (SMZ), a widely used sulfonamide antibiotic frequently detected in livestock waste streams, requires enhanced microbial degradation strategies to prevent its accumulation and associated environmental hazards. While several microbial strains with SMZ degradation capability have been isolated, comprehensive elucidation of metabolic pathways remains incomplete. This study identified Bacillus sp. strain DLY-11, exhibiting exceptional SMZ degradation performance, from thermally treated swine manure compost substrates. Under optimized parameters (5 % (v/v) bacterial inoculum, 59.7 degrees C operational temperature, pH 8.08 maintained with buffer system, and 0.4 g/L MgSO4 supplementation), the strain achieved 97.1 % elimination of 20 mg/L SMZ within 48-h incubation. Metabolic pathway analysis through detected intermediates revealed two distinct biodegradation mechanisms involving sulfonamide bond cleavage, oxidative hydroxylation, sulfur dioxide elimination, ring oxidation, amino group substitution, and glucuronic acid conjugation. These findings enhance understanding of sulfonamide antibiotic catabolism while offering a promising microbial resource for controlling veterinary antibiotic contamination in agro-industrial ecosystems.
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