Glycogen Synthase Kinase 3 beta (GSK3 beta) Regulates Myogenic Differentiation in Skeletal Muscle Satellite Cells of Sheep
文献类型： 外文期刊
作者： Yang, Jingquan 1 ; Yang, Haosen 2 ; Wang, Linjie 2 ; Zhou, Ping 1 ;
作者机构： 1.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Peoples R China
2.Sichuan Agr Univ, Coll Anim Sci & Technol, Chengdu 611130, Peoples R China
关键词： sheep; GSK3 beta; skeletal muscle; satellite cells; SB216763
期刊名称：ANIMALS （ 2021影响因子：3.231； 五年影响因子：3.312 ）
ISSN： 2076-2615
年卷期： 2022 年 12 卷 20 期
收录情况： SCI
摘要： Glycogen synthase kinase 3 beta (GSK3 beta) has a vital role in the regulation of many cellular processes. However, the role of GSK3 beta in muscle cell differentiation in sheep remains unknown. In this study, we investigated the function of GSK3 beta in skeletal muscle satellite cells (SMSCs) of sheep. An overexpression of GSK3 beta significantly inhibited myotube formation as well as the mRNA levels of myogenic genes (MyoD, MyoG, MyHC1, and MyHC2a) in sheep SMSCs. SB216763 treatment had a time-course effect on the phosphorylation levels of sheep GSK3 beta. In addition, reducing the activity of GSK3 beta lead to the promotion of sheep SMSCs differentiation as well as the mRNA levels of myogenic genes (MyoD, MyoG, MyHC1, and MyHC2a). This study illustrated the function of GSK3 beta to inhibit myogenesis in sheep SMSCs, which provided evidence for studying the mechanisms involved in the regulation of sheep SMSCs differentiation by GSK3 beta.
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