Discovery of an unconventional lamprey lymphocyte lineage highlights divergent features in vertebrate adaptive immune system evolution
文献类型： 外文期刊
作者： Huang, Yingyi 1 ; Liu, Xiang 1 ; Li, Shuo 1 ; Li, Chen 1 ; Wang, Hong-Yan 1 ; Liu, Qun 4 ; Chen, Jian-Yang 4 ; Zhang, Yingying 4 ; Li, Yanan 1 ; Zhang, Xianghui 1 ; Wang, Qian 1 ; Liu, Kaiqiang 1 ; Liu, Yu-Yan 1 ; Pang, Yue 7 ; Liu, Shanshan 8 ; Fan, Guangyi 4 ; Shao, Changwei 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainab, Qingdao, Shandong, Peoples R China
2.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Processes, Qingdao, Peoples R China
3.Qingdao Europe Adv Inst Life Sci, BGI Res, Qingdao, Peoples R China
4.BGI Res, Qingdao, Peoples R China
5.BGI Res, Qingdao Key Lab Marine Genom, Qingdao, Peoples R China
6.Univ Copenhagen, Dept Biol, Copenhagen, Denmark
7.Liaoning Normal Univ, Coll Life Sci, Dalian, Peoples R China
8.BGI Res, Shenzhen, Peoples R China
9.MGI Tech, Shenzhen, Peoples R China
期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）
ISSN：
年卷期： 2024 年 15 卷 1 期
页码：
收录情况： SCI
摘要： Lymphocyte receptors independently evolved in both jawed and jawless vertebrates with similar adaptive immune responses. However, the diversity of functional subtypes and molecular architecture in jawless vertebrate lymphocytes, comparable to jawed species, is not well defined. Here, we profile the gills, intestines, and blood of the lamprey, Lampetra morii, with single-cell RNA sequencing, using a full-length transcriptome as a reference. Our findings reveal higher tissue-specific heterogeneity among T-like cells in contrast to B-like cells. Notably, we identify a unique T-like cell subtype expressing a homolog of the nonlymphoid hematopoietic growth factor receptor, MPL-like (MPL-L). These MPL-L+T-like cells exhibit features distinct from T cells of jawed vertebrates, particularly in their elevated expression of hematopoietic genes. We further discovered that MPL-L+ VLRA(+) T-like cells are widely present in the typhlosole, gill, liver, kidney, and skin of lamprey and they proliferate in response to both a T cell mitogen and recombinant human thrombopoietin. These findings provide new insights into the adaptive immune response in jawless vertebrates, shedding new light on the evolution of adaptive immunity.
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