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Notch signaling leads to a slower progression of embryonic myogenic differentiation in Landrace than in Langtang pigs

文献类型： 外文期刊

作者： Cai, Shufang 1 ; Hu, Bin 1 ; Zhu, Qi 2 ; Duo, Tianqi 2 ; Wang, Xiaoyu 2 ; Tong, Xian 2 ; Luo, Xiaorong 2 ; Yuan, Renqiang 2 ; Chen, Yaosheng 2 ; Wang, Jing 3 ; Luo, Chenglong 1 ; Xing, Baosong 3 ; Mo, Delin 2 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Livestock & Poultry Breeding, Guangdong Publ Lab Anim Breeding & Nutr,Guangdong, Guangzhou 510640, Peoples R China

2.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510006, Peoples R China

3.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Henan Key Lab Farm Anim Breeding & Nutr Regulat, Zhengzhou 450002, Peoples R China

关键词： myogenic progenitor; MyoD; Pax7; embryonic myogenesis; differentiation

期刊名称：ACTA BIOCHIMICA ET BIOPHYSICA SINICA （ 影响因子：3.511； 五年影响因子：3.893 ）

ISSN： 1672-9145

年卷期： 2022 年 54 卷 8 期

页码：

收录情况： SCI

摘要： Delving into porcine embryonic myogenesis is the key to elucidate the complex regulation of breed-specific differences in growth performance and meat production. Increasing evidence proves that pigs with less meat production show earlier embryonic myogenesis, but little is known about the underlying mechanisms. In this study, we examine the longissimus dorsi muscle (LDM) by immunohistochemistry and confirm that the differentiation of myogenic progenitors is increased (P < 0.05) in Lantang (LT, fatty) pigs compared with that in Landrace (LR, lean) pigs, which results in more (P < 0.001) differentiated myoblasts (Pax7(-)/MyoD(+)) and less (P < 0.001) myogenic progenitors (Pax7(+)/MyoD(-)) in LT pigs at 35 days post-conception (35dpc). Additionally, embryonic myogenic progenitors isolated from LT pigs show greater (P < 0.001) differentiation capacity with earlier expression of MyoD compared with those from LR pigs. Moreover, Notch signaling is more active (P < 0.05) in LR pig myogenic progenitors than in LT pig myogenic progenitors. Inhibition of Notch signaling in LR myogenic progenitors suppresses Pax7 expression and increases MyoD expression, thus promoting myogenic differentiation. Consistently, the process of myogenic progenitors differentiating into myoblasts in ex vivo embryo limbs is accelerated when Notch signaling is inhibited. These results indicate that Notch signaling facilitates the maintenance of myogenic progenitors and antagonizes myogenic differentiation by promoting Pax7 expression and preventing MyoD expression in LR pigs.

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