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Sodium alginate coated ferritin as ACE inhibitory peptide carrier: Prolonged release property and enhanced transepithelial transport

文献类型： 外文期刊

作者： Li, Ying 1 ; Wang, Ziyin 1 ; Xia, Weirong 1 ; Chai, Zhi 1 ; Feng, Jin 1 ; Teng, Cong 1 ; Ma, Kaiyang 1 ; Hu, Xindi 1 ; Xu, Lujing 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Jiangsu, Peoples R China

2.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China

关键词： Ferritin; Sodium alginate; AHLL; Simulated digestion; Transepithelial transport

期刊名称：FOOD SCIENCE AND BIOTECHNOLOGY （ 影响因子：3.1； 五年影响因子：3.5 ）

ISSN： 1226-7708

年卷期： 2025 年 34 卷 9 期

页码：

收录情况： SCI

摘要： The application of Ala-His-Leu-Leu (AHLL), an angiotensin converting enzyme (ACE) inhibitory peptide, is limited due to its low stability. In this work, horse spleen apoferritin (HSF) deposited with a layer of sodium alginate (SA) was employed to carry AHLL. The HSF encapsulation and SA decoration exhibited remarkable protection capacity for loaded AHLL from UV irradiation and thermal treatment. The ACE inhibitory activity of AHLL-HSF@SA nanoparticles maintained 60%-75% within the digestion process since the compact structure and the coverage of enzyme reaction sites. Intestinal permeability investigation unveiled that HSF encapsulation facilitated the AHLL absorption, and the Papp value was (2.70 +/- 0.02) x 10-5 cm/s. Moreover, the transepithelial transport of free AHLL was primarily mediated through the paracellular pathway, whereas the transport of AHLL-HSF nanoparticles might rely on AP2-mediated endocytosis. Owing to positive effects on structural stability, release property and intestinal absorption, polysaccharides coated ferritin is a promising vehicle for peptides.

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