Hyaluronic acid-decorated lipid nanocarriers as novel vehicles for curcumin: Improved stability, cellular absorption, and anti-inflammatory effects
文献类型： 外文期刊
作者： Feng, Jin 1 ; Wang, Zhen 1 ; Huang, Wuyang 1 ; Zhao, Xingyu 1 ; Xu, Lujing 1 ; Teng, Cong 1 ; Li, Ying 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, 50 Zhongling St, Nanjing 210014, Peoples R China
2.Jiangsu Univ, Sch Food & Biol Engn, 301 Xuefu Rd, Zhenjiang 212013, Peoples R China
关键词： Nanostructured lipid carriers; Hyaluronic acid; Curcumin; Oral delivery; Receptor-mediated endocytosis; Anti-inflammatory capacity
期刊名称：FOOD CHEMISTRY （ 影响因子：9.8； 五年影响因子：9.7 ）
ISSN： 0308-8146
年卷期： 2025 年 463 卷
页码：
收录情况： SCI
摘要： This study aimed to investigate how hyaluronic acid interfacial decoration affects the stability, cellular absorption, and anti-inflammatory effects of curcumin-loaded nanostructured lipid carriers. Nanocarriers were synthesized with an ovalbumin single layer and ovalbumin/hyaluronic acid double, mixed, or conjugated layers. All nanocarriers were spherical (200-300 nm diameter), and their encapsulation efficiency exceeded 95 %. Among the layers, the conjugated one exhibited the highest elastic surface dilatational modulus of approximately 40 mN/m, and the longest curcumin half-life of 186.07 days at 4 degrees C. Spearman's correlation analysis showed a negative correlation (r = -0.6698) between the recrystallization index and curcumin stability. The layer's mechanical strength improved curcumin stability by preventing crystal transition. Hyaluronic acid decoration enhanced the curcumin uptake of Caco-2 cells by 1.96-2.48 folds. Among the layers, the conjugate one was the most effective because of its strong binding constant with the receptor. Hyaluronic acid decoration improved the anti-inflammatory effects of curcumin.
- 相关文献
作者其他论文 更多>>
-
Unraveling the key structural characteristics enhancing digestion resistance of wheat starch-mung bean hull polyphenols complexes
作者：Wang, Ziyin;Xu, Lujing;Teng, Cong;Chai, Zhi;Feng, Jin;Lu, Yifei;Hu, Xindi;Ma, Kaiyang;Li, Ying;Wang, Ziyin;Li, Ying;Yuan, Xingxing;Chen, Xin
关键词：Wheat starch; Mung bean hull polyphenols; Molecular interaction; Multi-scale structure; Digestibility
-
Sodium alginate coated ferritin as ACE inhibitory peptide carrier: Prolonged release property and enhanced transepithelial transport
作者：Li, Ying;Wang, Ziyin;Xia, Weirong;Chai, Zhi;Feng, Jin;Teng, Cong;Ma, Kaiyang;Hu, Xindi;Xu, Lujing;Li, Ying;Wang, Ziyin
关键词：Ferritin; Sodium alginate; AHLL; Simulated digestion; Transepithelial transport
-
Cold plasma reengineers peanut protein isolate: Unveiling changes in functionality, rheology, and structure
作者：Nasiru, Mustapha Muhammad;Feng, Jin;Song, Jiangfeng;Li, Chunyang;Boateng, Evans Frimpong;Alnadari, Fawze;Bako, Hadiza Kabir;Ibeogu, Henry Isaiah;Yan, Wenjing;Zhang, Jianhao;Liu, Huan;Zhang, Qingqiang;Masisi, Kabo;Roth, Chuon Mony;Zhang, Jianhao
关键词：Peanut protein isolate; Cold plasma; Rheology; Functional properties; Structural properties
-
Optimization of Ultrasonic-Enzymatic-Assisted Extraction of Flavonoids from Sea Buckthorn (Hippophae rhamnoides L.) Pomace: Chemical Composition and Biological Activities
作者：Suo, Wenyu;Suo, Wenyu;Wang, Wenzhe;Li, Dajing;Wu, Haihong;Huang, Wuyang;Ma, Yanhong;Liu, Haiyan
关键词：
Hippophae rhamnoides L.; flavonoids; ultrasonic-enzymatic-assisted extraction; antioxidant; alpha-glucosidase and alpha-amylase inhibition -
Dietary fiber from burdock root ameliorates functional constipation in aging rats by regulating intestinal motility
作者：Mo, Liya;Wang, Ling;Ma, Kaiyang;Song, Qiqi;Ma, Kaiyang;Li, Ying;Song, Jiangfeng
关键词：dietary fiber; burdock root; functional constipation; the aging; nutritional strategy
-
Comparative analysis of lipid profiles and aroma characteristics in pecan oils: Probing conventional and non-conventional extraction techniques
作者：Cui, Jingtao;Zhang, Tao;Jiang, Xinchen;Qian, Yaming;Zhu, Haijun;Cui, Li;Huang, Wuyang;Cui, Jingtao
关键词：Pecan oil; Extraction techniques; Foodomics analysis; Lipid profile; Volatile compound
-
Synergism between TLR4 and B. infantis in the development of the premature intestine
作者：Huang, Wuyang;Huang, Wuyang;Djebali, Karim;Cho, Ky Young;Gardner, Kimberly;Fasano, Alessio;Meng, Di;Walker, W. Allan;Djebali, Karim;Cho, Ky Young;Gardner, Kimberly
关键词：
