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Synergism between TLR4 and B. infantis in the development of the premature intestine

文献类型： 外文期刊

作者： Huang, Wuyang 1 ; Djebali, Karim 2 ; Cho, Ky Young 2 ; Gardner, Kimberly 2 ; Fasano, Alessio 2 ; Meng, Di 2 ; Walker, W. Allan 2 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing, Peoples R China

2.Harvard Med Sch, Massachusetts Gen Hosp Children, Mucosal Immunol & Biol Res Ctr, 16th St Bldg 114-3503, Charlestown, MA 02129 USA

3.UCL, Eastman Dent Inst, Dept Microbial Dis, Royal Free Campus,Rowland Hill St, London NW3 2PF, England

4.Hallym Univ, Dept Pediat, Kangnam Sacred Heart Hosp, Seoul, South Korea

5.Howard Univ, 2400 6th St NW, Washington, DC 20059 USA

期刊名称：PEDIATRIC RESEARCH （ 影响因子：3.1； 五年影响因子：3.7 ）

ISSN： 0031-3998

年卷期： 2025 年 98 卷 1 期

页码：

收录情况： SCI

摘要： BackgroundIntestinal microbiota has a role in early life maturation including maturation of intestinal immune function. However, the interaction of the TLR4 with colonizing bacteria in intestinal development is incompletely understood.MethodsAn established human immature small intestinal cell line, human fetal intestinal organoids, and wild-type (WT) and TLR4 gene knockout (TLR4 -/-) neonatal mice were used to test the synergism between the innate immune receptor TLR4 and postbiotics from Bifidobacteria longum subsp. infantis (B. infantis) in development of the premature intestine.ResultsTLR4-mediated postbiotics induced immature enterocyte proliferation and filamentous actin (F-actin) maturation both at the mRNA and protein levels. Proliferation of mRNA levels increased in wild-type mice but not in TLR4 -/- mice fed by postbiotics, both in the ileum and colon. Postbiotics can also change tight junction distribution in WT neonatal colon but not in TLR4 -/- mice.ConclusionsOur data suggest a novel regulation of intestinal development by a synergistic role of the innate immune receptor TLR4 and early life colonizing bacteria, such as B. infantis. This study should provide new insights into the mechanisms of intestinal maturation as well as opportunities to target novel approaches to NEC prevention and treatment.ImpactThe innate immune system and postbiotics affect immature intestinal development.The innate immune receptor TLR4 prevention of NEC.Mechanism of prevention of NEC.This is the first time this has been demonstrated in human fetal intestine.In vitro process for future clinical studies for prevention of NEC.

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