文献类型： 外文期刊

作者： Ahmad, Bushra ¹ ; Khan, Muhammad Rashid ² ; Jamil, Arshad ³ ; Ahmad, Muhammad Zulfiqar ⁴ ; Pervez, Sidra ¹ ; Claridge, Timothy D. W. ⁵ ; Odell, Barbara ⁵ ; Mccullagh, James S. O. ⁵ ;

作者机构： 1.Shaheed Benazir Bhutto Women Univ, Dept Biochem, Peshawar 25000, KP, Pakistan

2.Quaid I Azam Univ, Dept Biochem, Islamabad 45320, Pakistan

3.Univ Agr, Dept Plant Breeding & Genet, Dera Ismail Khan 29050, Pakistan

4.Jiangsu Acad Agr Sci, Inst Leisure Agr, Jiangsu Key Lab Hort Crop Genet Improvement, Nanjing, Jiangsu, Peoples R China

5.Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

关键词： Carissa opaca; Naringin; Ursolic acid; Antioxidant; Antifungal; Antimicrobial

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.2； 五年影响因子：5.4 ）

ISSN： 2212-4292

年卷期： 2024 年 57 卷

页码：

收录情况： SCI

摘要： Carissa opaca Stapf ex Haines is an edible fruit plant (Apocynaceae) traditionally used for the treatment of asthma, fever, diarrhea, hepatitis and cardiac problems. Five compounds named Naringin, Prunin, Ursolic acid, Uvaol and Procrim a, were isolated from C. opaca and tested for their antioxidant, and antimicrobial properties. Antioxidant activity was performed against various radicals i.e. DPPH, ABTS, -O2, -OH and non -radical e.g. H2O2. Naringin, Prunin and Ursolic acid were highly active against these radicals with significant IC50 values. All compounds were tested for their antibacterial activity against various Gram-positive and Gram-negative bacterial strains. All compounds were displaying MIC values in promising ranges. Antifungal activity was also determined using various fungal strains e.g. Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus and Fusarium solani. Naringin and Ursolic acid expressed significant inhibition of growth all fungal strains. It is concluded that these biologically active compounds isolated from edible plant C. opaca can be used against various free radical and infectious diseases.