您好，欢迎访问内蒙古农牧业科学院 机构知识库！
内蒙古农牧业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Proteomic analysis of fetal skin by iTRAQ reveals molecular signals underlying Inner Mongolia Cashmere goat hair follicle initiation

文献类型： 外文期刊

作者： Wang, Lele 1 ; Tian, Rugang 2 ; Wang, Gaofeng 3 ; Zhao, Meng 2 ; Zhang, Yanjun 4 ; Li, Jinquan 4 ;

作者机构： 1.Ulanqab Med Coll, Ulanqab, Peoples R China

2.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot, Peoples R China

3.Ulanqab Ctr Anim Dis Control & Prevent, Ulanqab, Peoples R China

4.Inner Mongolia Agr Univ, Hohhot, Peoples R China

5.Inner Mongolia Agr Univ, Coll Anim Sci, Inner Mongolia Autonomous Reg, Hohhot 010018, Peoples R China

关键词： ITRAQ; Cashmere goat; fetal skin; hair follicle; proteomics; clustering

期刊名称：ALL LIFE （ 影响因子：1.2； 五年影响因子：1.2 ）

ISSN： 2689-5293

年卷期： 2023 年 16 卷 1 期

页码：

收录情况： SCI

摘要： Cashmere goats produce wool from primary hair follicles (PHF)and cashmere from secondary hair follicles(SHF). Numerous genetic factors have been identified to affect HF formation, but the mechanism that controls the distinct morphogenesis of PHFs and SHFs remains unclear. To better describe goat's hair follicle proteome, we applied iTRAQ technology to study protein expression profiling from nine skin samples of cashmere goats in three fetal periods including 45-day-old embryos (E45), 55-day-old embryos (E55), 65-day-old embryos (E65). A total of 1172 proteins identified are expressed in fetal skin. The numbers of differentially expressed proteins in E45 vs. E55, E45 vs. E65, and E55 vs. E65 were 103, 144, and 118, respectively. Sixty-three proteins were constantly increased through the whole embryonic developmental stages of placode formation. Keratin 1, 4, 5, 10, 13, 15, 17, and 75 belonging to the hair keratin family (KRTs) were identified during keratinocyte proliferation. Some proteins involved in these pathways probably have a role in the HF and might be the mediators of HF initiation in Cashmere goats. Our systematic investigation identified some signaling factors that drive the large-scale cellular rearrangements necessary for HF initiation, which provide an insight into the fundamental mechanisms of cashmere growth.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：内蒙古农牧业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台