文献类型： 外文期刊
作者： Tang, Biao 1 ; Chang, Jiang 1 ; Zhang, Ling 3 ; Liu, Lizhang 4 ; Xia, Xiaodong 3 ; Hassan, Bachar H. 6 ; Jia, Xu 7 ; Yang 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, Hangzhou 310021, Zhejiang, Peoples R China
2.Zhejiang Acad Agr Sci, Lab Managing Biot & Chem Threats Qual & Safety Ag, Hangzhou 310021, Zhejiang, Peoples R China
3.Northwest Agr & Forestry Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China
4.Zhejiang Univ, Sch Med, Dept Pathogen Biol & Microbiol, Affiliated Hosp 2, Hangzhou 310058, Zhejiang, Peoples R China
5.Zhejiang Univ, Sch Med, Dept Gen Intens Care Unit, Affiliated Hosp 2, Hangzhou 310058, Zhejiang, Peoples R China
6.SUNY Stony Brook, 101 Nicolls Rd, Stony Brook, NY 11794 USA
7.Chengdu Med Coll, Noncoding RNA & Drug Discovery Key Lab Sichuan Pr, Chengdu 610500, Sichuan, Peoples R China
8.Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Zhejiang, Peoples R China
关键词： IncHI2; IncX4; mcr-1; Salmonella Ngor; Salmonella Goldcoast
期刊名称：ADVANCED BIOSYSTEMS
ISSN：
年卷期： 2020 年 4 卷 3 期
页码：
收录情况： SCI
摘要： Colistin acts as a last-resort antibiotic against lethal infections by carbapenem-resistant Enterobacterial pathogens. Enterobacteriaceae carrying mobile colistin resistance (MCR) genes are rapidly emerging and threatening human health and food safety. Despite mcr-1 being prevalent in Escherichia coli, its dissemination in Salmonella is not well characterized. Herein, two unusual serotypes of colistin-resistant Salmonella isolates are reported first, namely serotype Ngor (ST5399) and Goldcoast (ST2529). Using whole genome sequencing, it is shown that mcr-1 is located on the IncHI2-like plasmid pTB501 (188,527 bp) of strain SSDFZ54 and the IncX4-type plasmid pTB602 (33,303 bp) in strain SSDFZ69, respectively. Furthermore, the backbone, tra- and antimicrobial resistance genes relative variable regions in the mcr-1-bearing IncHI2 plasmids are systematically characterized. Phylogenetic analysis shows that all IncHI2-type plasmids from non-Chinese regions are clustered together, suggesting a possible Chinese origin. Taken together, these findings extend the understanding of Salmonella as a vehicle of mcr-1 carriage and distribution.
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