您好，欢迎访问浙江省农业科学院 机构知识库！
浙江省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Integrated Metabolome and Microbiome Analysis Reveals the Regulatory Effects of Fermented Soybean Meal on the Gut Microbiota of Late Gestation

文献类型： 外文期刊

作者： Li, Yantao 1 ; Fu, Lele 2 ; Chen, Yushi 2 ; Yang, Hua 2 ; Xiao, Yingping 3 ; Ren, Ying 1 ; Wang, Cheng 2 ;

作者机构： 1.Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China

2.Xianghu Lab, Hangzhou 311231, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Qual & Safety Agroprod, Hangzhou 310021, Peoples R China

关键词： gut microbiota; metabolite; fermentation; soybean meal; late gestation

期刊名称：FERMENTATION-BASEL （ 影响因子：3.3； 五年影响因子：3.5 ）

ISSN：

年卷期： 2025 年 11 卷 6 期

页码：

收录情况： SCI

摘要： Late gestation is a critical period for regulating maternal peripartum physiological metabolism and gut microbiota balance. Fermented diets have been widely recognized as effective exogenous nutritional interventions capable of modulating the maintenance of gut microbiota homeostasis. However, the mechanism through which fermented diets modulate the gut microbiota in late-gestation remains poorly understood. In this study, an in vitro fermentation model combined with chemical composition analysis, untargeted metabolomics, and high-throughput sequencing was employed to investigate the metabolic alterations during soybean meal (SBM) fermentation and the regulatory effects of fermented soybean meal (FSBM) on gut microbiota of late-gestation sows. The findings revealed that fermentation significantly increased the levels of crude protein, lactic acid, acid-soluble protein, lysine, histidine, and total amino acids of SBM. Conversely, the levels of crude fiber, NDF, ADF, starch, and non-starch polysaccharides were markedly reduced, compared to the unfermented group. A total of 941 differentially expressed metabolites were identified between SBM and FSBM. Specifically, FSBM elevated the levels of lactic acid, L-pyroglutamic acid, 2-aminoisobutyric acid, and tyrosine, while substantially decreasing the levels of raffinose, sucrose, and stachyose. Metabolic pathway analysis identified glutathione metabolism, tyrosine metabolism, and pantothenate and coenzyme A (CoA) biosynthesis as the key pathways involved in SBM fermentation. In vitro fermentation experiments demonstrated that FSBM substantially increased the production of short-chain fatty acids (SCFAs) and notably increased the relative abundance of sows gut commensal Lactobacillus and Limosilactobacillus in late gestation. In summary, this study demonstrated that co-fermentation with bacteria and enzymes pretreatment of soybean meal reduced fiber components and enriched bioactive metabolites, optimizing intestinal microbial composition and increasing SCFA production in late-pregnant period. The present study provides novel insights into the regulatory effects of fermented diets on gut microbiota in late-gestation period from the perspectives of nutritional composition and metabolites.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：浙江省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台