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Effect of short-chain chlorinated paraffins on metabolic profiling of male SD rats

文献类型： 外文期刊

作者： Geng, Ningbo 1 ; Luo, Yun 1 ; Cao, Rong 1 ; Song, Xiaoyao 1 ; Li, Fang 3 ; Wang, Feidi 4 ; Gong, Yufeng 1 ; Xing, Liguo 5 ;

作者机构： 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China

2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China

4.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, Hangzhou 310021, Peoples R China

5.Chem Ind Ltd, Safety Evaluat Ctr, Shenyang Res Inst, Shenyang 110021, Peoples R China

关键词： SCCPs; Metabolomic; Lipid metabolism; TCA cycle; Energy metabolism

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：7.963； 五年影响因子：7.842 ）

ISSN： 0048-9697

年卷期： 2021 年 750 卷

页码：

收录情况： SCI

摘要： The toxic effect of high-dose of short-chain chlorinated paraffins (SCCPs) has been extensively studied, however the possible health risks induced by SCCPs at low-dose remain largely unknown. In this study, a comprehensive toxicology analysis of SCCPs was conducted with the exposure levels from the environmental dose to the Lowest Observed Adverse Effect Level (LOAEL) of 100 mg/kg/day. General toxicology analysis revealed inconspicuous toxicity of the environmental dose of SCCPs, high dose SCCP exposure inhibited the growth rate and increased the liver weight of rat. Metabolomics analysis indicated that SCCP-induced toxicity was triggered at environmentally relevant doses. First, inhibition of energy metabolism was observed with the decrease in blood glucose and the dysfunction of TCA cycle, which may have contributed to lower body weight gain in rats exposed to a high dose of SCCPs. Second, the increase of free fatty acids indicated the acceleration of lipid metabolism to compensate for the energy deficiency caused by hypoglycemia. Lipid oxidative metabolism inevitably leads to oxidative stress and stimulates the up-regulation of antioxidant metabolites such as GSH and GSSH. The up-regulation of polyunsaturated fatty acids (PUFAs) and phospholipids composed of arachidonic acid indicates the occurrence of inflammation. Dysfunction of lipid metabolism can be an indicator of SCCP-induced liver injury. (C) 2020 Published by Elsevier B.V.

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