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Advances in the Application of Aptamer Biosensors to the Detection of Aminoglycoside Antibiotics

文献类型： 外文期刊

作者： Luan, Yunxia 1 ; Wang, Nan 1 ; Li, Cheng 1 ; Guo, Xiaojun 1 ; Lu, Anxiang 1 ;

作者机构： 1.Beijing Municipal Key Lab Agr Environm Monitoring, Beijing Res Ctr Agr Stand & Testing, Agr Product Qual & Safety Risk Assessment Lab, Dept Agr, Beijing 100097, Peoples R China

2.Jinzhou Med Univ, Coll Pharm, Jinzhou 121001, Peoples R China

关键词： aptamer; aminoglycoside antibiotic; antibiotic detection; biosensors

期刊名称：ANTIBIOTICS-BASEL （ 影响因子：4.639； 五年影响因子：4.849 ）

ISSN： 2079-6382

年卷期： 2020 年 9 卷 11 期

页码：

收录情况： SCI

摘要： Antibiotic abuse is becoming increasingly serious and the potential for harm to human health and the environment has aroused widespread social concern. Aminoglycoside antibiotics (AGs) are broad-spectrum antibiotics that have been widely used in clinical and animal medicine. Consequently, their residues are commonly found in animal-derived food items and the environment. A simple, rapid, and sensitive detection method for on-site screening and detection of AGs is urgently required. In recent years, with the development of molecular detection technology, nucleic acid aptamers have been successfully used as recognition molecules for the identification and detection of AGs in food and the environment. These aptamers have high affinities, selectivities, and specificities, are inexpensive, and can be produced with small batch-to-batch differences. This paper reviews the applications of aptamers for AG detection in colorimetric, fluorescent, chemiluminescent, surface plasmon resonance, and electrochemical sensors for the analysis in food and environmental samples. This study provides useful references for future research.

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