Genomic analysis of worldwide sheep breeds reveals PDGFD as a major target of fat-tail selection in sheep
文献类型： 外文期刊
作者： Dong, Kunzhe 1 ; Yang, Min 1 ; Han, Jiangang 1 ; Ma, Qing 5 ; Han, Jilong 2 ; Song, Ziyi 6 ; Luosang, Cuicheng 7 ; Gorkha 1 ;
作者机构： 1.Chinese Acad Agr Sci CAAS, Natl Germplasm Ctr Domest Anim Resources, Inst Anim Sci, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China
2.CAAS, Minist Agr & Rural Affairs, Key Lab Anim Poultry Genet Breeding & Reprod, Beijing 100193, Peoples R China
3.Augusta Univ, Med Coll Georgia, Dept Pharmacol & Toxicol, Augusta, GA 30912 USA
4.Shihezi Univ, Coll Anim Sci & Technol, Shihezi 832000, Peoples R China
5.Ningxia Acad Agr & Forestry Sci, Res Ctr Grass & Livestock, Yinchuan 750002, Ningxia, Peoples R China
6.Guangxi Univ, Coll Anim Sci & Technol, Nanning 530004, Guangxi, Peoples R China
7.Tibet Acad Agr & Anim Husb Sci, Res Inst Anim Sci, Lhasa 850000, Peoples R China
8.Chinese Acad Agr Sci CAAS, Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730050, Peoples R China
关键词： PDGFD; Fat-tailed sheep; Genomic scan; Fat deposit; Adipogenesis
期刊名称：BMC GENOMICS （ 影响因子：3.969； 五年影响因子：4.478 ）
ISSN： 1471-2164
年卷期： 2020 年 21 卷 1 期
页码：
收录情况： SCI
摘要： Background Fat tail is a unique trait in sheep acquired during domestication. Several genomic analyses have been conducted in sheep breeds from limited geographic origins to identify the genetic factors underlying this trait. Nevertheless, these studies obtained different candidates. The results of these regional studies were easily biased by the breed structures. Results To minimize the bias and distinguish the true candidates, we used an extended data set of 968 sheep representing 18 fat-tailed breeds and 14 thin-tailed breeds from around the world, and integrated two statistical tests to detect selection signatures, including Genetic Fixation Index (F-ST) and difference of derived allele frequency (Delta DAF). The results showed that platelet derived growth factor D (PDGFD) exhibited the highest genetic differentiation between fat- and thin-tailed sheep breeds. Analysis of sequence variation identified that a 6.8-kb region within the first intron of PDGFD is likely the target of positive selection and contains regulatory mutation(s) in fat-tailed sheep. Histological and gene expression analyses demonstrated that PDGFD expression is associated with maturation and hemostasis of adipocytes. Further retrospective analysis of public transcriptomic datasets revealed that PDGFD expression is down-regulated during adipogenesis in both human and mouse, and is higher in fat tissues of obese individuals than that in lean individuals. Conclusions These results reveal that PDGFD is the predominant factor for the fat tail phenotype in sheep by contributing to adiopogenesis and maintaining the hemostasis of mature adipocytes. This study provides insights into the selection of fat-tailed sheep and has important application to animal breeding, as well as obesity-related human diseases.
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