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Inhibitory effect of central ghrelin on steroid synthesis affecting reproductive health in female mice

文献类型： 外文期刊

作者： Deng Pan 1 ; Kun Wang 3 ; Cao, Guifang 1 ; Fan, Kuikui 1 ; Liu, Haodong 1 ; Li, Penghui 1 ; Li, Haijun 1 ; Du Chenguang 1 ;

作者机构： 1.Inner Mongolia Agr Univ, Coll Vet Med, Hohhot 010018, Peoples R China

2.Inner Mongolia Key Lab Basic Vet Sci, Hohhot 010018, Peoples R China

3.Hebei Acad Agr & Forestry Sci, Inst Grain & Oil Crops, Shijiazhuang 050000, Hebei, Peoples R China

4.Inner Mongolia Agr Univ, Vocat & Tech Coll, Baotou 014109, Peoples R China

关键词： Steroid hormone synthesis; Steroidogenic acute regulatory protein; Cytochrome P450 17A1; 38-hydroxysteroid dehydrogenase; Ghrelin

期刊名称：JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY （ 影响因子：4.292； 五年影响因子：4.216 ）

ISSN： 0960-0760

年卷期： 2020 年 204 卷

页码：

收录情况： SCI

摘要： Ghrelin is a 28-amino acid peptide hormone that regulates ovarian steroid hormone synthesis; however, there is limited evidence regarding the regulation of this pathway by ghrelin in mice ovary. Thus, we aimed to investigate whether central ghrelin action plays a role in murine reproductive health by inhibiting steroid synthesis. Further, we sought to examine the mechanism of central ghrelin action in ovarian steroid hormone synthesis. After the administration of intracerebroventricular ghrelin (1 nmol), we found reduced serum concentrations of oestradiol and progesterone and reduced secretion of follicle-stimulating hormone and luteinising hormone. Although ghrelin reduced 3 beta-hydroxysteroid dehydrogenase mRNA and protein levels in the hypothalamus, it did not affect the expression of steroidogenic acute regulatory protein and cytochrome P450 17A1. In the ovary, central ghrelin regulation indirectly inhibited the mRNA and protein levels of steroidogenic acute regulatory protein, cytochrome P450 17A1, and 3 beta-hydroxysteroid dehydrogenase. Moreover, no changes were observed in the expression of proliferating cell nuclear antigen and phosphorylation of extracellular signal-regulated kinase. We hypothesised that central ghrelin regulation suppressed serum oestradiol and progesterone levels by indirectly inhibiting the expression of steroidogenic acute regulatory protein, cytochrome P450 17A1, and 3 beta-hydroxysteroid dehydrogenase in the ovary. In this regulation, the suppressed secretion of the follicle-stimulating hormone and luteinising hormone in the pituitary by ghrelin could be involved. Furthermore, hypothalamic 3 beta-hydroxysteroid dehydrogenase expression is reduced by ghrelin injection.

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