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Effect of a high-collagen peptide diet on the gut microbiota and short-chain fatty acid metabolism

文献类型： 外文期刊

作者： Mei, Fengfeng 1 ; Duan, Zhouwei 3 ; Chen, Muxue 1 ; Lu, Jinfeng 1 ; Zhao, Meihui 1 ; Li, Laihao 2 ; Shen, Xuanri 1 ; Xia, 1 ;

作者机构： 1.Hainan Univ, Hainan Engn Res Ctr Aquat Resources Efficient Uti, Haikou 570228, Hainan, Peoples R China

2.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Minist Agr & Rural Affairs, Key Lab Aquat Prod Proc, Guangzhou 510300, Peoples R China

3.Hainan Acad Agr Sci, Inst Proc & Design Agroprod, Haikou 570228, Hainan, Peoples R China

4.Key Lab Food Nutr & Funct Food Hainan Prov, Haikou 570228, Hainan, Peoples R China

5.Minist Educ, Engn Res Ctr Utilizat Trop Polysaccharide Resourc, Haikou 570228, Hainan, Peoples R China

6.Hainan Univ, Coll Food Sci & Technol, Haikou 570228, Hainan, Peoples R China

关键词： Collagen peptide; Gut microbiota; SCFA metabolism; Valerate acid

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN： 1756-4646

年卷期： 2020 年 75 卷

页码：

收录情况： SCI

摘要： In this study, a total of 24 male Sprague Dawley rats were randomly divided into 3 group (Collagen peptide of Salmon salar skin group, Ss-SCP; Collagen peptide of Tilapia nilotica skin group, Tn-SCP and Model control group, MC) to investigate the impact of a high-collagen peptide diet on the gut microbiota and host health. After 16 days intervention, the body weights of the Ss-SCP and Tn-SCP intervention groups were significantly increased and the liver index was also remarkably higher than that of the MC group. The acetic acid and propionic acid levels in feces were both significantly increased in the diet high-collagen peptide groups and valerate acid level was lower than that in the MC group. With the intervention of a high-dose collagen peptide diet, the gut microbiota of the groups was shifted with increased abundance of Lactobacillus, Unidentified-Prevotellaceae, Allobaculum, and Parasutterella, whereas the Tn-SCP administration have caused low abundance of Anaerostipes, Blautia, and Fusicatenibacter. The relative abundance of Allobaculum as well as Parasutterella was positively correlated with propionic acid and acetic acid levels, respectively. In addition, Allobaculum abundance was negatively correlated with valerate acid level. The serum valerate acid content was potentially harmful to rat health and significantly increased in the groups intervened with collagen peptide. All together, these results showed that administration of diet high-collagen peptide shifts the gut microbiota in rats and induced a disturbance in short-chain fatty acid metabolism which is potentially harmful to health.

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