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Actions of putative embryokines on development of the preimplantation bovine embryo to the blastocyst stage

文献类型： 外文期刊

作者： Sang, Lei 1 ; Ortiz, W. 1 ; Xiao, Y. 1 ; Estrada-Cortes, E. 1 ; Jannaman, E. A. 1 ; Hansen, P. J. 1 ;

作者机构： 1.Univ Florida, DH Barron Reprod & Perinatal Biol Res Program, Dept Anim Sci, Gainesville, FL 32611 USA

2.Univ Florida, Genet Inst, Gainesville, FL 32611 USA

3.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou 350013, Fujian, Peoples R China

4.Inst Nacl Invest Forestales Agr & Pecuarias, Campo Expt Ctr Altos Jalisco, Tepatitlan De Morelos 47600, Jalisco, Mexico

5.Grp Matsuda, Dept Nutr Anim, Rodovia Raposo Tavares,SP 270,Km 575, Alvares Machado, SP, Brazil

关键词： embryokine; embryo; blastocyst; pregnancy

期刊名称：JOURNAL OF DAIRY SCIENCE （ 影响因子：4.034； 五年影响因子：4.354 ）

ISSN： 0022-0302

年卷期： 2020 年 103 卷 12 期

页码：

收录情况： SCI

摘要： Once it enters the uterus at d 4 to 5 after ovulation, the preimplantation bovine embryo is controlled in its development by regulatory signaling molecules from the mother called embryokines. Here, several cell-signaling molecules whose genes are expressed in the endometrium during d 5 to 7 after estrus were tested for the ability to affect the competence of the embryo for further development and the characteristics of the resultant blastocysts. Molecules tested were C-natriuretic peptide (CNP), IL-8, bovine morphogenetic protein 4 (BMP-4), IL-6, and leukemia inhibitory factor (LIF). None of the cell-signaling molecules tested improved the competence of the embryo to become a blastocyst; in fact, BMP-4 decreased development. All molecules modified attributes of the blastocyst formed in culture. In particular, CNP increased the number of cells in the 1CM, whereas IL-8 decreased inner cell mass cell numbers and tended to increase the proportion of blastocysts that were hatching or hatched. In addition, BMP-4 decreased the proportion of blastocysts that were hatching. Interleukin-6 and, to a lesser extent, LIF activated the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in the inner cell mass, and LIF increased the percent of cells in the blastocyst that were positive for both NANOG and phosphorylated (activated) STAT3. In conclusion, our results indicate that CNP, IL-8, IL-6, LIF, and BMP-4 can modify embryonic development of the cow in a manner that affects characteristics of the resultant blastocyst. Further research is required to understand how these changes in characteristics of the blastocyst would affect competence of the embryo to establish and maintain pregnancy.

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