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Atlas of receptor genes expressed by the bovine morula and corresponding ligand-related genes expressed by uterine endometrium

文献类型： 外文期刊

作者： Sang, Lei 1 ; Xiao, Yao 4 ; Jiang, Zongliang 5 ; Forde, Niamh 6 ; Tian, Xiuchun Cindy 7 ; Lonergan, Patrick 8 ; Hansen 1 ;

作者机构： 1.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou, Fujian, Peoples R China

2.Univ Florida, DH Barron Reprod & Perinatal Biol Res Program, Dept Anim Sci, Gainesville, FL 32611 USA

3.Univ Florida, Genet Inst, Gainesville, FL 32611 USA

4.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan, Shandong, Peoples R China

5.Louisiana State Univ, AgCtr, Sch Anim Sci, Baton Rouge, LA 70803 USA

6.Univ Leeds, Dept Discovery & Translat Sci, Leeds, W Yorkshire, England

7.Univ Connecticut, Dept Anim Sci, Storrs, CT USA

8.Univ Coll, Sch Agr & Food Sci, Dublin, Ireland

关键词： cell signaling; embryo; endometrium; morula; receptors

期刊名称：MOLECULAR REPRODUCTION AND DEVELOPMENT （ 影响因子：2.609； 五年影响因子：3.47 ）

ISSN： 1040-452X

年卷期： 2021 年 88 卷 10 期

页码：

收录情况： SCI

摘要： Regulation of the mammalian embryo involves cell-signaling molecules produced by the maternal oviduct and endometrium. Here, datasets on the transcriptome of the gestational Days 5 and 6 bovine morula and Day 5 maternal endometrium were examined to identify receptor genes expressed by the morula and expression of the corresponding ligand-related genes in the endometrium. A total of 175 receptor genes were identified in the morula, including 48 encoding for growth factors or WNT signaling molecules, 25 for cytokines and chemokines, 35 involved in juxtacrine and matricellular signaling and 25 encoding for receptors for small molecules. Some of the highly-expressed pairs of endometrial ligand and embryo receptor genes included MDK and its receptors ITGB1, SDC4 and LRP2, WNT5A (RYK), VEGFA (ITGB1), GPI (AMFR), and the hedgehog proteins IHH and DHH (HHIP). The most highly expressed receptors for small molecules were GPRC5C (retinoic acid receptor), PGRMC1 (progesterone), and CHRNB2 (acetylcholine). There were also 84 genes encoding for cell signaling ligands expressed by the morula, with the most highly expressed being GPI, AIMP1, TIMP1, IK, and CCN2. The atlas of receptor and ligand genes should prove useful for understanding details of the communication between the embryo and mother that underlies optimal embryonic development.

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