Selenium enrichment improves anti-proliferative effect of oolong tea extract on human hepatoma HuH-7 cells
文献类型： 外文期刊
作者： Wang, Qi 1 ; Guan, Xuefang 1 ; Lai, Chengchun 1 ; Gao, Huiying 1 ; Zheng, Yafeng 3 ; Huang, Juqing 1 ; Lin, Bin 1 ;
作者机构： 1.Fujian Acad Agr Sci, Inst Agr Engn, Fuzhou 350003, Peoples R China
2.Fujian Key Lab Agr Prod Food Proc, Fuzhou 350003, Peoples R China
3.Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China
关键词： Oolong tea; Selenium; Human hepatoma cell; Anti-proliferative effect; Apoptosis
期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）
ISSN： 0278-6915
年卷期： 2021 年 147 卷
页码：
收录情况： SCI
摘要： Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 mu g selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 mu g selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 mu g/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that SeTE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry.
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