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Construction of pH/glutathione responsive chitosan nanoparticles by a self-assembly/self-crosslinking method for photodynamic therapy

文献类型： 外文期刊

作者： Yang, Ziming 1 ; Li, Puwang 2 ; Chen, Yu 1 ; Gan, Qiang 1 ; Feng, Zhipan 1 ; Jin, Yiguang 3 ; Zhou, Chuang 2 ; He, Zuyu 2 ;

作者机构： 1.Beijing Inst Technol, Beijing 100081, Peoples R China

2.Chinese Acad Trop Agr Sci, South Subtrop Crop Res Inst, Zhanjiang 524091, Guangdong, Peoples R China

3.Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China

关键词： Amphiphilic sulfhydryl chitosan; Nanoparticles; Photosensitizer; Photodynamic therapy; Tumor

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN： 0141-8130

年卷期： 2021 年 167 卷

页码：

收录情况： SCI

摘要： A novel pH/glutathione (GSH) multi-responsive chitosan nanoparticles (NPs) material has been successfully designed and prepared by a self-assembly/self-crosslinking method for photodynamic therapy (PDT), which overcomes the shortcomings of traditional photosensitizer carriers, such as poor chemical stability, low loading efficiency and single-responsive photosensitizer release. Amphiphilic sulfhydryl chitosan (SA-CS-NAC) is first prepared by modifying chitosan (CS) with stearic acid (SA) and N-acetyl-L-cysteine (NAC), and then subject to self-assembly and self-crosslinking in the presence of photosensitizer, indocyanine green (ICG), to form the ICG-loaded amphiphilic sulfhydryl chitosan nanoparticles (SA-CS-NAC@ICG NPs). The ICG entrapment efficiency and loading efficiency of the NPs are found to be 95.2% and 27.6%, respectively. The multi-responsive ICG release of the NPs to the low pH and high GSH content of the microenvironment in tumor cells is successfully achieved. Under the laser irradiation, the SA-CS-NAC@ICG NPs produce the amount of reactive oxygen species (ROS) twice of that generated by free ICG under the same conditions. The in vitro cell experiment confirmed the strong cellular uptake ability, low biotoxicity and good tumor inhibition of the NPs. Our work has provided a new strategy for the targeted photosensitizer delivery for PDT. (C) 2020 Elsevier B.V. All rights reserved.

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