Cucurbitacin IIb induces apoptosis and cell cycle arrest through regulating EGFR/MAPK pathway
文献类型： 外文期刊
作者： Liang, Yuan 1 ; Zhang, Tiehua 1 ; Ren, Li 1 ; Jing, Siyuan 1 ; Li, Zhuolin 2 ; Zuo, Peng 2 ; Li, Tiezhu 2 ; Wang, Yongjun 2 ;
作者机构： 1.Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China
2.Jilin Acad Agr Sci, Inst Agr Biotechnol, Changchun 130033, Peoples R China
关键词： Cucurbitacin IIb (CuIIb); Epidermal growth factor receptor (EGFR); Tyrosine kinase inhibitor (TKI); Apoptosis; Cell cycle arrest; Binding mode
期刊名称：ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY （ 影响因子：4.86； 五年影响因子：4.462 ）
ISSN： 1382-6689
年卷期： 2021 年 81 卷
页码：
收录情况： SCI
摘要： Epidermal growth factor receptor (EGFR) is considered as a valid target in the clinical trials of anticancer therapy and tyrosine kinase inhibitors (TKIs) of EGFR are approved for cancer treatments. In present work, cucurbitacin IIb (CuIIb) was confirmed to exhibit the proliferation inhibitory activity in A549 cells. CuIIb induced apoptosis via STAT3 pathway, which was mitochondria-mediated and caspase-dependent. CuIIb also suppressed the cell cycle and induced G2/M phase cell cycle arrest. CuIIb was capable of suppressing the signal transmitting of the EGFR/mitogen-activated protein kinase (MAPK) pathway which was responsible for the apoptosis and cell cycle arrest. Homogeneous time-resolved fluorescence (HTRF) analysis demonstrated that the kinase activity of EGFR was inhibited by CuIIb. Molecular docking suggested that the CuIIb-EGFR binding fundamentally depends on the contribution of both hydrophobic and hydrogen-bonding interactions. Hence CuIIb may serve as a potential EGFR TKI.
- 相关文献
作者其他论文 更多>>
-
Intercropping outweighs straw incorporation driving community and functional diversity of microarthropods after 5 years of tillage practices
作者：Liu, Yuhang;Gao, Qiang;Sun, Xin;Wang, Bin;Sun, Xin;Liu, Yuhang;Wang, Yongjun;Yao, Fanyun;Wang, Bin;Sun, Xin;Wu, Haitao;Sun, Xin
关键词：Maize-peanut intercropping; Microarthropods; Straw incorporation; Sustainable agriculture
-
Psoralen and Isopsoralen Activate Nuclear Factor Erythroid 2-Related Factor 2 Through Interaction With Kelch-Like ECH-Associated Protein 1
作者：Lv, Chengyu;Wang, Song;Sun, Chang;Chen, Yihao;Wang, Chao;Yuan, Cuiping;Qin, Fengxian;Li, Tiezhu;Liu, Jing
关键词：antioxidant response element; isopsoralen; molecular docking; Nrf2; psoralen
-
Leveraging cover crop functional traits and nitrogen synchronization for yield-optimized waxy corn production systems
作者：Sun, Mengjing;Zhang, Long;Zhou, Jiangkuo;Liu, Ziping;Peng, Cong;Jia, Zechen;Lv, Yanjie;Wang, Yongjun;Sun, Mengjing;Zhang, Long;Zhou, Jiangkuo;Liu, Ziping;Peng, Cong;Jia, Zechen;Lv, Yanjie;Wang, Yongjun;Sun, Mengjing;Zhang, Long;Zhou, Jiangkuo;Liu, Ziping;Peng, Cong;Jia, Zechen;Lv, Yanjie;Wang, Yongjun
关键词：waxy corn; cover crop; yield; nitrogen use efficiency; path analysis
-
Integrating physiological, metabolome and transcriptome revealed the response of maize seeds to combined cold and high soil moisture stresses
作者：Meng, Xiangzeng;Wang, Lichun;Wang, Yongjun;Meng, Xiangzeng;Cao, Yujun;Lv, Yanjie;Wang, Lichun;Wang, Yongjun
关键词：
-
The effects of a combination of maize/peanut intercropping and residue return on soil microbial nutrient limitation in maize fields
作者：Yao, Fanyun;Cao, Yujun;Liang, Jie;Liu, Xiaodan;Liu, Zhiming;Lv, Yanjie;Wei, Wenwen;Xu, Wenhua;Wang, Yongjun;Qi, Wei;Wang, Yongjun;Yu, Yang;Li, Xiang;Feng, Jian
关键词：Soil nutrients; Microbial biomass; Extracellular enzymes; C:N:P stoichiometry; Nutrient limitation
-
Thriving in adversity: Understanding how maize seeds respond to the challenge of combined cold and high humidity stress
作者：Meng, Xiangzeng;Chen, Denglong;Wang, Yongjun;Wang, Lichun;Meng, Xiangzeng;Chen, Denglong;Lv, Yanjie;Xu, Wenhua;Wang, Yongjun;Wang, Lichun
关键词：Seed germination; Abiotic stress; Antioxidant enzyme; Metabolomic; Glycolysis
-
Elimination of Intraspecific Competition Does Not Improve Maize Leaf Physiological and Biochemical Responses to Topsoil Degradation
作者：Zhang, Shan;Jia, Zechen;Lv, Yanjie;Wang, Yongjun;Zhang, Shan;Guo, Zhongxiao;Lv, Yanjie;Wang, Yongjun;Zhang, Xiaolong;Liu, Kaichang
关键词：topsoil depth; maize planting density; intraspecific competition; nitrogen metabolism enzymes; photosynthesis enzymes; yield variability
