Interfacially Self-Assembled Mutifunctional Protein Thin Films for Accelerated Wound Healing
文献类型： 外文期刊
作者： Geng, Yajiao 1 ; Hu, Juntao 2 ; Gao, Yuze 1 ; Guo, Jialiang 1 ; Hao, Hao 1 ; Hao, Fengjie 1 ; Li, Tiezhu 3 ; Chen, Yihao 3 ; Huang, Wei 3 ; Luo, Quan 1 ;
作者机构： 1.Jilin Univ, Sch Life Sci, Key Lab Mol Enzymol & Engn, Minist Educ, Changchun 130012, Peoples R China
2.Jilin Univ, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China
3.Jilin Acad Agr Sci, Inst Agrofood Technol, Changchun 130033, Peoples R China
4.Jilin Univ, Coll Chem, Ctr Supramol Chem Biol, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China
期刊名称：ACS MACRO LETTERS （ 影响因子：5.1； 五年影响因子：5.7 ）
ISSN：
年卷期： 2024 年
页码：
收录情况： SCI
摘要： The design of mutifunctional protein films for large-area spatially ordered arrays of functional components holds great promise in the field of biomedical applications. Herein, interfacial electrostatic self-assembly was employed to construct a large-scale protein thin film by inducing electrostatic interactions between three bovine serum albumin (BSA)-coated nanoclusters and cetyltrimethylammonium bromide (CTAB), leading to their spontaneous organization and uniform distribution at the oil-water interface. This protein film demonstrated excellent multienzyme functions, high antibacterial activity, and pH-responsive drug release capability. Therefore, it can accelerate the wound closure process through a synergistic effect that includes reducing local blood glucose levels, regulating cellular oxidative stress, eradicating bacteria, and promoting cell proliferation.
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