Quercetin ameliorates hepatic fat accumulation in high-fat diet-induced obese mice via PPARs
文献类型： 外文期刊
作者： Zhao, Jingqi 1 ; Sun, Yantong 2 ; Yuan, Cuiping 3 ; Li, Tiezhu 3 ; Liang, Yuan 1 ; Zou, Haoyang 1 ; Zhang, Jie 1 ; Ren, Li 1 ;
作者机构： 1.Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China
2.Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Peoples R China
3.Jilin Acad Agr Sci, Inst Agrofood Technol, Changchun 130033, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：6.1； 五年影响因子：6.5 ）
ISSN： 2042-6496
年卷期： 2023 年 14 卷 3 期
页码：
收录情况： SCI
摘要： As a natural pigment in food, quercetin possesses multiple biological activities and plays a crucial role in regulating metabolic syndrome. Herein, we aim to explore the potential mechanism of quercetin to ameliorate hepatic fat accumulation. In vivo experiments showed that quercetin significantly relieved inflammation response by decreasing the serum TNF-alpha and IL-6 levels and also improved high-fat diet-induced hepatic steatosis without other organ injuries. Quercetin can effectively reduce lipid aggregation and down-regulate the protein expression of PCK1 in HepG2 cells induced by oleic acid and palmitic acid, indicating that inhibiting gluconeogenesis leads to hepatic fat accumulation reduction. Furthermore, molecular docking results suggested that quercetin can bind to both PPAR alpha and PPAR gamma, with an even more potent binding affinity than indeglitazar, a pan-agonist of PPARs. In conclusion, quercetin may regulate gluconeogenesis to ameliorate hepatic fat accumulation via targeting PPAR alpha/gamma.
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