文献类型： 外文期刊
作者： Li, Qingnan 1 ; Pan, Xiangchun 2 ; Li, Nian 2 ; Gong, Wentao 2 ; Chen, Yaosheng 1 ; Yuan, Xiaolong 2 ;
作者机构： 1.Sun Yat Sen Univ, Guangzhou Higher Educ Mega Ctr, Sch Life Sci, State Key Lab Biocontrol, North Third Rd, Guangzhou 510006, Peoples R China
2.South China Agr Univ, Coll Anim Sci, Natl Engn Res Ctr Breeding Swine Ind, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Peoples R China
3.Guangdong Lab Animals Monitoring Inst, Guangdong Prov Key Lab Lab Anim, Guangzhou 510260, Peoples R China
关键词： hypothalamus; puberty; circRNAs; pubertal genes
期刊名称：GENES （ 影响因子：4.096； 五年影响因子：4.339 ）
ISSN：
年卷期： 2021 年 12 卷 1 期
页码：
收录情况： SCI
摘要： The disorders of puberty have shown negative outcomes on health of mammals, and the hypothalamus is thought to be the main regulator of puberty by releasing GnRH. Many studies show that the circular RNAs (circRNAs) might be implicated in the timing of puberty in mammals. However, the circRNAs in the hypothalamus of gilts have not been explored. To profile the changes and biological functions of circRNAs in the hypothalamus during the onset of puberty, RNA-seq was utilized to establish pre-, in-, and post-pubertal hypothalamic circRNAs profiles. In this study, the functions of hypothalamic circRNAs were enriched in the signaling pathway of neurotrophin, progesterone-mediated oocyte maturation, oocyte meiosis, insulin, ErbB, and mTOR, which have been highly suggested to be involved in the timing of puberty. Furthermore, 53 circRNAs were identified to be putative hypothalamus-specific expressed circRNAs, and some of them were exclusively expressed in the one of three pubertal stages. Moreover, 22 differentially expressed circRNAs were identified and chosen to construct the circRNA-miRNA-gene network. Moreover, 10 circRNAs were found to be driven by six puberty-related genes (ESR1, NF1, APP, ENPP2, ARNT, and DICER1). Subsequently, the expression changes of several circRNAs were confirmed by RT-qPCR. Collectively, the preliminary results of hypothalamic circRNAs provided useful information for the investigation of the molecular mechanism for the timing of puberty in gilts.
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