文献类型： 外文期刊

作者： Teng, Jinyan ¹ ; Gao, Yahui ¹ ; Yin, Hongwei ⁴ ; Bai, Zhonghao ⁵ ; Liu, Shuli ⁷ ; Zeng, Haonan ¹ ; Bai, Lijing ⁴ ; Cai, Zexi ¹ ; Zhao, Bingru ⁸ ; Li, Xiujin ⁹ ; Xu, Zhiting ¹ ; Lin, Qing ¹ ; Pan, Zhangyuan ¹⁰ ; Yang, Wenjing ⁸ ; Yu, Xiaoshan ⁶ ; Guan, Dailu ¹⁰ ; Hou, Yali ¹² ; Keel, Brittney N. ¹⁴ ; Rohrer, Gary A. ¹⁴ ; Lindholm-Perry, Amanda K. ¹⁴ ; Oliver, William T. ¹⁴ ; Ballester, Maria ¹⁵ ; Crespo-Piazuelo, Daniel ¹⁵ ; Quintanilla, Raquel ¹⁵ ; Canela-Xandri, Oriol ¹ ; Rawlik, Konrad ¹⁶ ; Xia, Charley ¹⁷ ; Yao, Yuelin ¹⁹ ; Zhao, Qianyi ¹ ; Yao, Wenye ²⁰ ; Yang, Liu ⁴ ; Li, Houcheng ¹ ; Zhang, Huicong ¹ ; Liao, Wang ¹ ; Chen, Tianshuo ¹ ; Karlskov-Mortensen, Peter ²¹ ; Fredholm, Merete ²¹ ; Amills, Marcel ²² ; Clop, Alex ²² ; Giuffra, Elisabetta ²⁵ ; Wu, Jun ¹ ; Cai, Xiaodian ¹ ; Diao, Shuqi ¹ ; Pan, Xiangchun ¹ ; Wei, Chen ¹ ; Li, Jinghui ¹ ; Cheng, Hao ¹ ; Wang, Sheng ²⁶ ; Su, Guosheng ¹ ; Sahana, Goutam ¹ ; Lund, Mogens Sando ¹ ; Dekkers, Jack C. M. ²⁷ ; Kramer, Luke ²⁷ ; Tuggle, Christopher K. ²⁷ ; Corbett, Ryan ²⁷ ; Groenen, Martien A. M. ¹ ; Madsen, Ole ¹ ; Godia, Marta ²³ ; Rocha, Dominique ²⁵ ; Charles, Mathieu ²⁵ ; Li, Cong-jun ² ; Pausch, Hubert ²⁸ ; Hu, Xiaoxiang ²⁹ ; Frantz, Laurent ³⁰ ; Luo, Yonglun ³² ; Lin, Lin ³² ; Zhou, Zhongyin ¹ ; Zhang, Zhe ¹ ; Chen, Zitao ³⁵ ; Cui, Leilei ³⁶ ; Xiang, Ruidong ⁴⁰ ; Shen, Xia ⁴² ; Li, Pinghua ⁴⁵ ; Huang, Ruihua ⁴⁵ ; Tang, Guoqing ⁴⁶ ; Li, Mingzhou ⁴⁶ ; Zhao, Yunxiang ⁴⁷ ; Yi, Guoqiang ⁴ ; Tang, Zhonglin ⁴ ; Jiang, Jicai ⁴⁸ ; Zhao, Fuping ¹ ; Yuan, Xiaolong ⁴⁹ ; Liu, Xiaohong ⁴⁹ ; Chen, Yaosheng ¹ ; Xu, Xuewen ¹ ; Zhao, Shuhong ⁵⁰ ; Zhao, Pengju ⁵⁰ ; Haley, Chris ⁶ ; Zhou, Huaijun ¹ ; Wang, Qishan ¹ ; Pan, Yuchun ¹ ; Ding, Xiangdong ⁸ ; Ma, Li ¹ ; Li, Jiaqi ¹ ; Navarro, Pau ⁶ ; Zhang, Qin ⁵⁴ ; Li, Bingjie ¹ ; Tenesa, Albert ⁶ ; Li, Kui ⁴ ; Liu, George E. ² ; Zhang, Zhe ¹ ; Fang, Lingzhao ⁶ ;

作者机构： 1.South China Agr Univ SCAU, Coll Anim Sci, Guangdong Prov Key Lab Agro Anim Genom & Mol Bree, Natl Engn Res Ctr Breeding Swine Ind,State Key La, Guangzhou, Peoples R China

2.ARS, Anim Genom & Improvement Lab, Henry A Wallace Beltsville Agr Res Ctr, USDA, Beltsville, MD 20705 USA

3.Univ Maryland, Dept Anim & Avian Sci, College Pk, MD USA

4.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr,Shenzhen Branch, Key Lab Livestock & Poultry Multi Omics MARA, Shenzhen, Peoples R China

5.Aarhus Univ, Ctr Quantitat Genet & Genom, Aarhus, Denmark

6.Univ Edinburgh, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland

7.Westlake Univ, Sch Life Sci, Hangzhou, Peoples R China

8.China Agr Univ, Coll Anim Sci & Technol, Beijing, Peoples R China

9.Zhongkai Univ Agr & Engn, Coll Anim Sci & Technol, Guangdong Prov Key Lab Waterfowl Hlth Breeding, Guangzhou, Peoples R China

10.Univ Calif Davis, Dept Anim Sci, Davis, CA USA

11.Chinese Acad Agr Sci, Inst Anim Sci, Beijing, Peoples R China

12.Chinese Acad Sci, Beijing Inst Genom, Beijing, Peoples R China

13.China Natl Ctr Bioinformat, Beijing, Peoples R China

14.USDA, ARS, US Meat Anim Res Ctr, Clay Ctr, NE USA

15.Inst Recerca Tecnol Agroalimentaries IRTA, Anim Breeding & Genet Programme, Caldes De Montbui, Spain

16.Univ Edinburgh, Baillie Gifford Pandem Sci Hub, Edinburgh, Midlothian, Scotland

17.Univ Edinburgh, Lothian Birth Cohort studies, Edinburgh, Midlothian, Scotland

18.Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland

19.Univ Edinburgh, Sch Informat, Edinburgh, Midlothian, Scotland

20.Wageningen Univ & Res, Anim Breeding & Genom, Wageningen, Netherlands

21.Univ Copenhagen, Dept Vet & Anim Sci, Anim Genet Bioinformat & Breeding, Copenhagen, Denmark

22.Univ Autonoma Barcelona, Ctr Res Agr Genom CRAG, Dept Anim Genet, CSIC IRTA UAB UB, Bellaterra, Spain

23.Univ Autonoma Barcelona, Dept Ciencia Anim & Dels Aliments, Bellaterra, Spain

24.CSIC, Barcelona, Spain

25.Paris Saclay Univ, INRAE, AgroParisTech, GABI, Jouy En Josas, France

26.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Yunnan, Peoples R China

27.Iowa State Univ, Dept Anim Sci, Ames, IA USA

28.Swiss Fed Inst Technol, Animal Genom, Univ Str 2, Zurich, Switzerland

29.China Agr Univ, Coll Biol Sci, State Key Lab Agrobiotechnol, Beijing, Peoples R China

30.Ludwig Maximilians Univ Munchen, Dept Vet Sci, Palaeogen Grp, Munich, Germany

31.Queen Mary Univ London, Sch Biol & Behav Sci, London, England

32.Aarhus Univ, Dept Biomed, Aarhus, Denmark

33.Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark

34.Qingdao Europe Adv Inst Life Sci, Lars Bolund Inst Regenerat Med, BGI Res, Qingdao, Peoples R China

35.Zhejiang Univ, Coll Anim Sci, Dept Anim Sci, Hangzhou, Peoples R China

36.Nanchang Univ, Sch Life Sci, Nanchang, Jiangxi, Peoples R China

37.Nanchang Univ, Human Aging Res Inst, Nanchang, Jiangxi, Peoples R China

38.Jiangxi Key Lab Human Aging, Nanchang, Jiangxi, Peoples R China

39.UCL, UCL Genet Inst, London, England

40.Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic, Australia

41.Agr Victoria, AgriBio, Ctr AgriBiosci, Bundoora, Vic, Australia

42.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China

43.Fudan Univ, Greater Bay Area Inst Precis Med, Ctr Intelligent Med Res, Guangzhou, Peoples R China

44.Univ Edinburgh, Usher Inst, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland

45.Nanjing Agr Univ, Inst Swine Sci, Nanjing, Peoples R China

46.Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key, Chengdu, Peoples R China

47.Guangxi Univ, Coll Anim Sci & Technol, Nanning, Peoples R China

48.North Carolina State Univ, Dept Anim Sci, Raleigh, NC USA

49.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou, Peoples R China

50.Huazhong Agr Univ, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan, Peoples R China

51.Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan, Peoples R China

52.Zhejiang Univ, Hainan Inst, Yazhou Bay Sci Tech City, Yongyou Ind Pk, Sanya, Peoples R China

53.Univ Edinburgh, Royal Dick Sch Vet Studies, Roslin Inst, Edinburgh, Midlothian, Scotland

54.Shandong Agr Univ, Coll Anim Sci & Technol, Tai An, Shandong, Peoples R China

55.Scotlands Rural Coll SRUC, Roslin Inst Bldg, Edinburgh, Midlothian, Scotland

期刊名称：NATURE GENETICS （ 影响因子：30.8； 五年影响因子：37.4 ）

ISSN： 1061-4036

年卷期： 2024 年 56 卷 1 期

页码：

收录情况： SCI

摘要： The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biological discovery and exploitation in animal breeding and human biomedicine. Here we show results from the pilot phase of PigGTEx by processing 5,457 RNA-sequencing and 1,602 whole-genome sequencing samples passing quality control from pigs. We build a pig genotype imputation panel and associate millions of genetic variants with five types of transcriptomic phenotypes in 34 tissues. We evaluate tissue specificity of regulatory effects and elucidate molecular mechanisms of their action using multi-omics data. Leveraging this resource, we decipher regulatory mechanisms underlying 207 pig complex phenotypes and demonstrate the similarity of pigs to humans in gene expression and the genetic regulation behind complex phenotypes, supporting the importance of pigs as a human biomedical model.