您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Transcriptomic profiling of gastrointestinal tracts in dairy cattle during lactation reveals molecular adaptations for milk synthesis

文献类型： 外文期刊

作者： Gao, Yahui 1 ; Liu, George E. 1 ; Ma, Li 2 ; Fang, Lingzhao 4 ; Li, Cong-jun 1 ; Baldwin, Ransom L. 1 ;

作者机构： 1.ARS, Anim Genom & Improvement Lab, Beltsville Agr Res Ctr, USDA, Beltsville, MD 20705 USA

2.Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA

3.South China Agr Univ, Coll Anim Sci, State Key Lab Livestock & Poultry Breeding, Guangdong Prov Key Lab Agroanim Genom & Mol Breedi, Guangzhou 510642, Peoples R China

4.Aarhus Univ, Ctr Quantitat Genet & Genom QGG, Aarhus, Denmark

期刊名称：JOURNAL OF ADVANCED RESEARCH （ 影响因子：13.0； 五年影响因子：11.6 ）

ISSN： 2090-1232

年卷期： 2025 年 71 卷

页码：

收录情况： SCI

摘要： During lactation, dairy cattle's digestive tract requires significant adaptations to meet the increased nutrient demands for milk production. As we attempt to improve milk-related traits through selective pressure, it is crucial to understand the biological functions of the epithelia of the rumen, small intestine, and colonic tissues in response to changes in physiological state driven by changes in nutrient demands for milk synthesis. In this study, we obtained a total of 108 transcriptome profiles from three tissues (epithelia of the colon, duodenum, and rumen) of five Holstein cows, spanning eight time points from the early, mid, late lactation periods to the dry period. On average 97.06% of reads were successfully mapped to the reference genome assembly ARS-UCD1.2. We analyzed 27,607 gene expression patterns at multiple periods, enabling direct comparisons within and among tissues during different lactation stages, including early and peak lactation. We identified 1645, 813, and 2187 stage-specific genes in the colon, duodenum, and rumen, respectively, which were enriched for common or specific biological functions among different tissues. Time series analysis categorized the expressed genes within each tissue into four clusters. Furthermore, when the three tissues were analyzed collectively, 36 clusters of similarly expressed genes were identified. By integrating other comprehensive approaches such as gene co-expression analyses, functional enrichment, and cell type deconvolution, we gained profound insights into cattle lactation, revealing tissue-specific characteristics of the gastrointestinal tract and shedding light on the intricate molecular adaptations involved in nutrient absorption, immune regulation, and cellular processes for milk synthesis during lactation. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

  • 相关文献
作者其他论文 更多>>
  • Integrating large-scale meta-analysis of genome-wide association studies improve the genomic prediction accuracy for combined pig populations

    作者：Cai, Xiaodian;Zhang, Wenjing;Wei, Chen;Gao, Yahui;Li, Jiaqi;Zhang, Zhe;Gao, Ning;Wu, Xibo;Si, Jinglei;Yin, Tong

    关键词：combined population; genomic prediction; heritability enrichment; meta-analysis of genome-wide association studies

  • A resource of longitudinal RNA-seq data of Holstein cow rumen, duodenum, and colon epithelial cells during the lactation cycle

    作者：Gao, Yahui;Liu, George E.;Li, Cong-jun;Baldwin, Ransom L.;Gao, Yahui;Ma, Li;Gao, Yahui

    关键词：Holstein cattle; Gene expression; Gastrointestinal tract tissues; Lactation; Functional genome; Molecular genetics

  • Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of 232 complex traits in pigs

    作者：Xu, Zhiting;Lin, Qing;Cai, Xiaodian;Zhong, Zhanming;Teng, Jinyan;Zeng, Haonan;Gao, Yahui;Wei, Chen;Zhou, Jun;Zhang, Wenjing;Zhang, Xiaoke;Shi, Shaolei;Wu, Jun;Diao, Shuqi;Liu, Yuqiang;Pan, Xiangchun;Feng, Xueyan;Liu, Ruiqi;Su, Zhanqin;Chang, Chengjie;Zhu, Qianghui;Wu, Yuwei;Zhang, Hao;Yuan, Xiaolong;Li, Jiaqi;Zhang, Zhe;Li, Bingjie;Gao, Yahui;Liu, George E.;Gao, Yahui;Ma, Li;Cai, Zexi;Bai, Zhonghao;Su, Guosheng;Sahana, Goutam;Lund, Mogens Sando;Fang, Lingzhao;Wang, Xiaoqing;Shi, Liangyu;Zhao, Fuping;Wang, Xue;Wang, Yi;Zhang, Zipeng;Ding, Xiangdong;Lin, Yu;Tang, Guoqing;Li, Mingzhou;Li, Xuewei;Liu, Shuli;Yin, Hongwei;Bai, Lijing;Li, Kui;Zhou, Zhongyin;Wang, Qishan;Pan, Yuchun;Xu, Zhong;Peng, Xianwen;Mei, Shuqi;Mo, Delin;Liu, Xiaohong;Chen, Yaosheng;Liu, Yang;Xiang, Ruidong;Xiang, Ruidong;Shen, Xia;Shen, Xia;Shen, Xia;Li, Pinghua;Huang, Ruihua;Li, Pinghua;Huang, Ruihua;Ballester, Maria;Crespo-Piazuelo, Daniel;Amills, Marcel;Clop, Alex;Amills, Marcel;Karlskov-Mortensen, Peter;Fredholm, Merete;Zhang, Qin;Zhao, Yunxiang

    关键词：pig; meta-GWAS; PigGTEx; molQTL; complex traits

  • Mapping the regulatory genetic landscape of complex traits using a chicken advanced intercross line

    作者：Zhu, Xiaoning;Li, Chong;Ren, Jiangli;Song, Ran;Wang, Yuzhe;Hu, Xiaoxiang;Zhu, Xiaoning;Shu, Dingming;Qu, Hao;Zhu, Xiaoning;Bai, Zhonghao;Fang, Lingzhao;Luo, Chenglong;Shu, Dingming;Chen, Peng;Qu, Hao;Ren, Jiangli;Song, Ran;Wang, Yuzhe;Hu, Xiaoxiang;Wang, Yuzhe;Hu, Xiaoxiang

    关键词：

  • Genetic regulation of gene expression across multiple tissues in chickens

    作者：Guan, Dailu;Wang, Ying;Zhou, Huaijun;Bai, Zhonghao;Zhu, Di;Li, Houcheng;Buitenhuis, Albert Johannes;Sahana, Goutam;Lund, Mogens Sando;Fang, Lingzhao;Zhu, Xiaoning;Zhu, Di;Wang, Yuzhe;Hu, Xiaoxiang;Zhong, Conghao;Lan, Fangren;Li, Xiaochang;Sun, Congjiao;Yang, Ning;Zhong, Conghao;Lan, Fangren;Li, Xiaochang;Sun, Congjiao;Yang, Ning;Hou, Yali;Pan, Zhangyuan;Si, Wei;Diao, Shuqi;Gao, Yahui;Teng, Jinyan;Xu, Zhiting;Lin, Qing;Li, Zhenhui;Nie, Qinghua;Zhang, Xiquan;Zhang, Zhe;Yao, Yuelin;Yao, Yuelin;Zhao, Bingru;Gao, Yahui;Liu, George E.;Gao, Yahui;Zou, Dong;Wang, Ruizhen;Xu, Tianyi;Zhang, Zhang;Zou, Dong;Wang, Ruizhen;Xu, Tianyi;Zhang, Zhang;Wang, Ruizhen;Zhang, Zhang;Yin, Hongwei;Shi, Shourong;Shao, Dan;Degalez, Fabien;Lagarrigue, Sandrine;Wang, Mingshan;Peng, Minsheng;Wang, Mingshan;Peng, Minsheng;Rocha, Dominique;Charles, Mathieu;Smith, Jacqueline;Watson, Kellie;Warren, Wesley;Frantz, Laurent;Frantz, Laurent;Larson, Greger;Lamont, Susan J.;Si, Wei;Zhao, Xin;Li, Bingjie;Zhang, Haihan;Luo, Chenglong;Shu, Dingming;Qu, Hao;Luo, Wei;Li, Zhenhui;Nie, Qinghua;Zhang, Xiquan;Li, Zhenhui;Nie, Qinghua;Zhang, Xiquan;Xiang, Ruidong;Xiang, Ruidong;Xiang, Ruidong;Liu, Shuli;Cheng, Hans

    关键词：

  • Preliminary exploration of mRNA, lncRNA, and miRNA expressions in the bovine jejunum unveils novel aspects of Mycobacterium avium subspecies paratuberculosis infections

    作者：Gao, Yahui;Han, Bo;Sun, Dongxiao;Gao, Yahui;Cao, Jie

    关键词：Paratuberculosis; RNA-seq; sRNA-seq; Holstein cattle

  • The ChickenGTEx portal: a pan-tissue catalogue of regulatory variants shaping transcriptomic and phenotypic diversity

    作者：Hou, Yali;Li, Xin;Hou, Yali;Li, Xin;Zou, Dong;Xu, Tianyi;Yuan, Zhixiang;Zhang, Zhang;Zou, Dong;Xu, Tianyi;Yuan, Zhixiang;Zhang, Zhang;Chu, Qin;Zhan, Bujie;Wang, Ruizhen;Guan, Dailu;Zhou, Huaijun;Wang, Wannian;Feng, Xiao;Zhu, Xiaoning;Bai, Zhonghao;Hu, Xiaoxiang;Gao, Yahui;Yin, Hongwei;Fang, Lingzhao

    关键词：

置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台