Mapping the regulatory genetic landscape of complex traits using a chicken advanced intercross line
文献类型： 外文期刊
作者： Zhu, Xiaoning 1 ; Li, Chong 1 ; Luo, Chenglong 4 ; Bai, Zhonghao 3 ; Shu, Dingming 2 ; Chen, Peng 4 ; Ren, Jiangli 1 ; Song, Ran 1 ; Fang, Lingzhao 3 ; Qu, Hao 2 ; Wang, Yuzhe 1 ; Hu, Xiaoxiang 1 ;
作者机构： 1.China Agr Univ, Coll Biol Sci, State Key Lab Anim Biotech Breeding, Beijing, Peoples R China
2.State Key Lab Swine & Poultry Breeding Ind, Guangzhou, Peoples R China
3.Aarhus Univ, Ctr Quantitat Genet & Genom QGG, Aarhus, Denmark
4.Guangdong Acad Agr Sci, Inst Anim Sci, Guangdong Key Lab Anim Breeding & Nutr, Guangzhou, Peoples R China
5.China Agr Univ, Natl Res Facil Phenotyp & Genotyp Anal Model Anim, Beijing, Peoples R China
6.China Agr Univ, Frontiers Sci Ctr Mol Design Breeding, MOE, Beijing, Peoples R China
期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）
ISSN：
年卷期： 2025 年 16 卷 1 期
页码：
收录情况： SCI
摘要： Complex traits exhibit a highly polygenic architecture that complicates gene mapping and molecular characterization. As a model organism for birds, chickens possess high-quality reference panels, functional annotations, and molecular quantitative trait locus maps. However, the genetic mechanisms underlying growth traits have not been systematically analyzed. Here, we develop a 16-generation advanced intercross line of chickens to enhance informative recombination and identify 154 single-gene quantitative trait loci. We use multiple co-localization methods to establish a network landscape of tissue-specific regulatory mutations and functional gene relationships. We leverage gene-clustering and restoration quantitative trait loci within the omnigenic model framework to elucidate the genetic regulation system of growth traits. Cross-species comparisons show the conserved functions of growth-related genes and divergent features of regulatory mechanisms in mammals and birds.
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