Cryptosporidial Infection Suppresses Intestinal Epithelial Cell MAPK Signaling Impairing Host Anti-Parasitic Defense
文献类型： 外文期刊
作者： He, Wei 1 ; Li, Juan 2 ; Gong, Ai-Yu 2 ; Deng, Silu 2 ; Li, Min 2 ; Wang, Yang 2 ; Mathy, Nicholas W. 2 ; Feng, Yaoyu 1 ; Xi 1 ;
作者机构： 1.South China Agr Univ, Coll Vet Med, Ctr Emerging & Zoonot Dis, Guangzhou 510642, Peoples R China
2.Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, Omaha, NE 68198 USA
3.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangzhou 510640, Peoples R China
关键词： MAPK; p38; MAPK; Cryptosporidium; cryptosporidiosis; intestinal epithelium; defense
期刊名称：MICROORGANISMS （ 影响因子：4.128； ）
ISSN：
年卷期： 2021 年 9 卷 1 期
页码：
收录情况： SCI
摘要： Cryptosporidium is a genus of protozoan parasites that infect the gastrointestinal epithelium of a variety of vertebrate hosts. Intestinal epithelial cells are the first line of defense and play a critical role in orchestrating host immunity against Cryptosporidium infection. To counteract host defense response, Cryptosporidium has developed strategies of immune evasion to promote parasitic replication and survival within epithelial cells, but the underlying mechanisms are largely unclear. Using various models of intestinal cryptosporidiosis, we found that Cryptosporidium infection caused suppression of mitogen-activated protein kinase (MAPK) signaling in infected murine intestinal epithelial cells. Whereas expression levels of most genes encoding the key components of the MAPK signaling pathway were not changed in infected intestinal epithelial cells, we detected a significant downregulation of p38/Mapk, MAP kinase-activated protein kinase 2 (Mk2), and Mk3 genes in infected host cells. Suppression of MAPK signaling was associated with an impaired intestinal epithelial defense against C. parvum infection. Our data suggest that cryptosporidial infection may suppress intestinal epithelial cell MAPK signaling associated with the evasion of host antimicrobial defense.
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