Cryptosporidial Infection Suppresses Intestinal Epithelial Cell MAPK Signaling Impairing Host Anti-Parasitic Defense
文献类型： 外文期刊
作者： He, Wei 1 ; Li, Juan 2 ; Gong, Ai-Yu 2 ; Deng, Silu 2 ; Li, Min 2 ; Wang, Yang 2 ; Mathy, Nicholas W. 2 ; Feng, Yaoyu 1 ; Xi 1 ;
作者机构： 1.South China Agr Univ, Coll Vet Med, Ctr Emerging & Zoonot Dis, Guangzhou 510642, Peoples R China
2.Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, Omaha, NE 68198 USA
3.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangzhou 510640, Peoples R China
关键词： MAPK; p38; MAPK; Cryptosporidium; cryptosporidiosis; intestinal epithelium; defense
期刊名称：MICROORGANISMS （ 影响因子：4.128； ）
ISSN：
年卷期： 2021 年 9 卷 1 期
页码：
收录情况： SCI
摘要： Cryptosporidium is a genus of protozoan parasites that infect the gastrointestinal epithelium of a variety of vertebrate hosts. Intestinal epithelial cells are the first line of defense and play a critical role in orchestrating host immunity against Cryptosporidium infection. To counteract host defense response, Cryptosporidium has developed strategies of immune evasion to promote parasitic replication and survival within epithelial cells, but the underlying mechanisms are largely unclear. Using various models of intestinal cryptosporidiosis, we found that Cryptosporidium infection caused suppression of mitogen-activated protein kinase (MAPK) signaling in infected murine intestinal epithelial cells. Whereas expression levels of most genes encoding the key components of the MAPK signaling pathway were not changed in infected intestinal epithelial cells, we detected a significant downregulation of p38/Mapk, MAP kinase-activated protein kinase 2 (Mk2), and Mk3 genes in infected host cells. Suppression of MAPK signaling was associated with an impaired intestinal epithelial defense against C. parvum infection. Our data suggest that cryptosporidial infection may suppress intestinal epithelial cell MAPK signaling associated with the evasion of host antimicrobial defense.
- 相关文献
作者其他论文 更多>>
-
RNA m7G methylation regulators and targets significantly contribute to chronic obstructive pulmonary disease
作者：Zhu, Chenyu;Tan, Luyi;Zhang, Xinyu;Cheng, Wenli;Li, Min;Zhang, Wenjuan;Chen, Yibo
关键词：COPD; m7G; METTL1; CAT; Bioinformatics analysis
-
Structure-Based Virtual Screening of Potential Inhibitors Targeting the Prolyl-tRNA Synthetase (PRS) in Eimeria tenella: Insights from Molecular Docking, ADMET Studies, and Molecular Dynamics Simulations
作者：Cai, Haiming;Liao, Shenquan;Li, Juan;Lv, Minna;Lin, Xuhui;Song, Yongle;Chen, Xiangjie;Zhu, Yibin;Zhang, Jianfei;Qi, Nanshan;Sun, Mingfei
关键词：avian coccidiosis; prolyl-tRNA synthetase;
Eimeria tenella ; docking protocol; molecular dynamics simulations; ADMET -
Global m6A RNA and whole 5mC DNA methylation specifically contribute to cell replicative and premature senescence induced by extrinsic oxidative stress
作者：Zhu, Chenyu;Huang, Tingting;Fu, Jiaqi;Li, Min;Tan, Luyi;Zhang, Xinyu;Cheng, Wenli;Lai, Caiyun;Zhang, Wenjuan;Wang, Zhangying;Zhang, Wenji
关键词：H2O2; N6-methyladenosine; 5-methylcytosine; premature senescence; epigenetics
-
Development of a single-cell cloning technique for isolation of Pentatrichomonas hominis: a promising tool for diagnosing Trichomonas spp. infections in the pig breeding industry
作者：Zhu, Yibin;Cai, Haiming;Liao, Shenquan;Li, Juan;Lv, Minna;Lin, Xuhui;Hu, Junjing;Song, Yongle;Chen, Xiangjie;Yin, Lijun;Zhang, Jianfei;Qi, Nanshan;Sun, Mingfei;Fang, Siyun;Wang, Dingai;Yan, Zhuanqiang;Shen, Hanqin
关键词：
Trichomonas spp.; Isolation method; Single-cell cloning -
Research note: The critical role of the interaction between Eimeria tenella invasion protein RON2 and host receptor annexin A2 in mediating parasite invasion
作者：Ni, Junli;Chen, Xiangjie;Sun, Yunyun;Zhu, Yibin;Cai, Haiming;Song, Yongle;Lv, Minna;Li, Juan;Liao, Shenquan;Qi, Nanshan;Sun, Mingfei;Zhang, Jianfei;Lin, Xuhui;Ni, Junli;Sun, Yunyun;Gu, Youfang;Liu, Xinchao
关键词：Avian coccidia; Eimeria tenella; RON2; Invasion; Protein; receptor interactions
-
Prevalence and genetic diversity of Pentatrichomonas hominis in pig populations in Guangdong and Anhui Provinces, China
作者：Lu, Pengyun;Zhu, Yibin;Cai, Haiming;Liao, Shenquan;Qi, Nanshan;Lv, Minna;Lin, Xuhui;Song, Yongle;Chen, Xiangjie;Zhang, Jianfei;Li, Juan;Sun, Mingfei;Lu, Pengyun;Shen, Hanqin;Fang, Siyun;Wang, Dingai;Yan, Zhuanqiang
关键词：
Pentatrichomonas hominis ; Pig infection; Zoonotic potential; Prevalence; Genetic diversity -
Genome-Wide Analysis of the Maize LBD Gene Family Reveals a Role for ZmLBD12 in the Development of Lateral Roots
作者：Wang, Shifeng;Wang, Yang;Zhong, Jianbing;Huang, Jun;Xu, Wenlin;Zhai, Lihong;Gong, Qingyou;Li, Gaoke
关键词：maize; LBD gene family;
ZmLBD12 ; function analysis; lateral root
