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Supplemental Choline Modulates Growth Performance and Gut Inflammation by Altering the Gut Microbiota and Lipid Metabolism in Weaned Piglets

文献类型： 外文期刊

作者： Qiu, Yueqin 1 ; Liu, Shilong 2 ; Hou, Lei 2 ; Li, Kebiao 2 ; Wang, Li 2 ; Gao, Kaiguo 2 ; Yang, Xuefen 2 ; Jiang, Zongyon 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangzhou, Peoples R China

2.State Key Lab Livestock & Poultry Breeding, Guangzhou, Peoples R China

3.Minist Agr & Rural Affairs, Key Lab Anim Nutr & Feed Sci South China, Guangzhou, Peoples R China

4.Guangdong Prov Key Lab Anim Breeding & Nutr, Guangzhou, Peoples R China

5.Guangdong Lab Lingnan Modern Agr, Maoming Branch, Guangzhou, Peoples R China

6.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou, Peoples R China

关键词： choline; bile acids; lipid use; growth performance; gut inflammation; gut microbiota; bacterial metabolites; weaned piglets

期刊名称：JOURNAL OF NUTRITION （ 影响因子：4.798； 五年影响因子：5.718 ）

ISSN： 0022-3166

年卷期： 2021 年 151 卷 1 期

页码：

收录情况： SCI

摘要： Background: Whether dietary choline and bile acids affect lipid use via gut microbiota is unclear. Objectives: This study aimed to investigate the effect of choline and bile acids on growth performance, lipid use, intestinal immunology, gut microbiota, and bacterial metabolites in weaned piglets. Methods: A total of 128 weaned piglets [Duroc x (Landrace x Yorkshire), 21-d-old, 8.21 0.20 kg body weight (BW)] were randomly allocated to 4 treatments (8 replicate pens per treatment, each pen containing 2 males and 2 females; n = 32 per treatment) for 28 d. Piglets were fed a control diet (CON) or the CON diet supplemented with 597 mg choline/kg (C), 500 mg bile acids/kg (BA) or both (C + BA) in a 2 x 2 factorial design. Growth performance, intestinal function, gut microbiota, and metabolites were determined. Results: Compared with diets without choline, choline supplementation increased BW gain (6.13%), average daily gain (9.45%), gain per feed (8.18%), jejunal lipase activity (60.2%), and duodenal IL10 gene expression (51%), and decreased the mRNA abundance of duodenal TNFA (TNF alpha) (40.7%) and jejunal toll-like receptor 4 (32.9%) (P < 0.05); additionally, choline increased colonic butyrate (29.1%) and the abundance of Lactobacillus (42.3%), while decreasing the bile acid profile (55.8% to 57.6%) and the abundance of Parabacteroides (75.8%), Bacteroides (80.7%), and unidentifiedRuminococcaceae (32.5%) (P < 0.05). Compared with diets without BA, BA supplementation decreased the mRNA abundance of colonic TNFA (37.4%), NF-KB p65 (42.4%), and myeloid differentiation factor 88 (42.5%) (P < 0.01); BA also increased colonic butyrate (20.9%) and the abundance of Lactobacillus (39.7%) and Faecalibacterium (71.6%) and decreased that of Parabacteroides (67.7%) (P < 0.05). Conclusions: Choline supplementation improved growth performance and prevented gut inflammation in weaned piglets by altering gut microbiota and lipid metabolism. BA supplementation suppressed intestinal inflammation with no effect on growth performance, which was associated with changed gut microbiota and metabolites. J Nutr 2021;151:20- 29.

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