Coexistence and characterization of Tet(X5) and NDM-3 in the MDR-Acinetobacter indicus of duck origin
文献类型： 外文期刊
作者： Tang, Biao 1 ; Yang, Hua 1 ; Jia, Xu 5 ; Feng, Youjun 3 ;
作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, Hangzhou 310021, Zhejiang, Peoples R China
3.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Pathogen Biol & Microbiol, Hangzhou 310058, Zhejiang, Peoples R China
4.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Gen Intens Care Unit, Hangzhou 310058, Zhejiang, Peoples R China
5.Chengdu Med Coll, Noncoding RNA & Drug Discovery Key Lab Sichuan Pr, Chengdu 610500, Sichuan, Peoples R China
6.Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Zhejiang, Peoples R China
关键词： Coexistence; Tet(X5); NDM-3; Tigecycline resistance; Carbapenem resistance; Acinetobacter indicus
期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）
ISSN： 0882-4010
年卷期： 2021 年 150 卷
页码：
收录情况： SCI
摘要： Tigecycline and carbapenem are last-resort antibiotics for serious infections caused by pathogens with multi-drug resistance (MDR). Whereas, bacterial pathogens with co-resistance to tigecycline and carbapenem are poorly addressed. Here we report a tigecycline- and carbapenem-resistant Acinetobacter indicus strain HY20 of duck origin, which co-produces Tet(X5) and NDM-3. Tet(X5) is harbored by a novel plasmid pAI01 (116,992 bp long), which carries 10 antimicrobial resistance genes (AMRs), and heavy metal resistance system cobalt-zinc-cadmium (czc) gene cluster. Unlike that tet(X5) is located in the res tet(X5) xerD segment of plasmid, the chromosomal bla(NDM-3) is flanked by insertion ISAba125. Collectively, our result represents an example of co-carriage of tet(X5) and bla(NDM-3), heightening the importance of AMR surveillance needed in poultry production.
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