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Abundance of tigecycline resistance genes and association with antibiotic residues in Chinese livestock farms

文献类型： 外文期刊

作者： Fu, Yulin 1 ; Chen, Yiqiang 2 ; Liu, Dejun 1 ; Yang, Dawei 3 ; Liu, Zhihai 4 ; Wang, Yingyu 1 ; Wang, Jiayi 2 ; Wang, Xue 1 ;

作者机构： 1.China Agr Univ, Beijing Key Lab Detect Technol Anim Derived Food, Coll Vet Med, Beijing 100193, Peoples R China

2.China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

3.China Inst Vet Drug Control, Beijing 100081, Peoples R China

4.Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China

5.Huazhong Agr Univ, Natl Lab Vet Drug Safety Evaluat, Wuhan 430070, Peoples R China

6.Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Peoples R China

7.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Nanjing 210014, Peoples R China

8.Murdoch Univ, Res & Innovat Off, Murdoch, WA 6150, Australia

9.Zhejiang Agr & Forestry Univ, Coll Anim Sci & Technol, China Australia Joint Lab Anim Hlth Big Data Anal, Hangzhou 311300, Peoples R China

关键词： tet(X); tmexCD1-toprJ1; Feces; Antibiotic resistance

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：10.588； 五年影响因子：10.129 ）

ISSN： 0304-3894

年卷期： 2021 年 409 卷

页码：

收录情况： SCI

摘要： The discovery of plasmid-mediated tet(X) variants and efflux pump gene tmexCD1-toprJ1 conferring bacteria resistance to tigecycline has compromised glycylcycline as the last line of defense against infection, which poses serious threat to public health. Herein, real-time quantitative PCR was used to detect the abundance of seven tigecycline resistance genes (TRGs), including six tet(X) variants and tmexCD1-toprJ1, and insertion sequences ISCR2 and IS26. Then, the concentrations of nine antibiotics were quantified in fecal samples collected from 157 livestock farms in four Chinese provinces. TRGs, especially tet(X4), tmexCD1-toprJ1, and insertion sequences ISCR2 and IS26, were more abundant in chicken feces than in pig and cattle feces, suggesting the greater risk for the propagation of TRGs in chicken feces. Positive correlations (rho = 0.3741-0.8275, P < 0.0001) between ISCR2/ IS26 and TRGs (except tet(X1)) further demonstrated that ISCR2 mediates the transfer of tet(X3), tet(X4), and tet (X5) and that IS26 plays a certain role for the mobilization of tet(X4) and tmexCD1-toprJ1. Tetracyclines had no positive correlation with the abundance of TRGs (except tet(X1)), meanwhile florfenicol and tiamulin were positively correlated with TRGs. However, further research is needed to confirm whether or not florfenicol and tiamulin are potential driving factors of TRG accumulation.

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