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Newcastle Disease Virus Inhibits the Proliferation of T Cells Induced by Dendritic Cells In Vitro and In Vivo

文献类型： 外文期刊

作者： Nan, Fu Long 1 ; Zheng, Wei 3 ; Nan, Wen Long 4 ; Yu, Tong 2 ; Xie, Chang Zhan 2 ; Zhang, He 2 ; Xu, Xiao Hong 1 ; Li, Ch 1 ;

作者机构： 1.Jilin Univ, Coll Vet Med, Coll Anim Sci, Changchun, Peoples R China

2.Acad Mil Med Sci, Inst Mil Vet Med, Changchun, Peoples R China

3.964Hosp PLA Joint Logist, Changchun, Peoples R China

4.China Anim Hlth & Epidemiol Ctr, Qingdao, Peoples R China

5.Yanbian Univ, Coll Agr, Yanji, Peoples R China

6.Changchun Univ Chinese Med, Acad Workstn, Changchun, Peoples R China

7.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing, Peoples R China

8.Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China

关键词： Newcastle disease virus; dendritic cells; antigen presentation; phenotypic maturation; immunosuppression; proliferation of T cells

期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：7.561； 五年影响因子：7.624 ）

ISSN： 1664-3224

年卷期： 2021 年 11 卷

页码：

收录情况： SCI

摘要： Newcastle disease virus (NDV) infects poultry and antagonizes host immunity via several mechanisms. Dendritic cells (DCs) are characterized as specialized antigen presenting cells, bridging innate and adaptive immunity and regulating host resistance to viral invasion. However, there is little specific knowledge of the role of DCs in NDV infection. In this study, the representative NDV lentogenic strain LaSota was used to explore whether murine bone marrow derived DCs mature following infection. We examined surface molecule expression and cytokine release from DCs as well as proliferation and activation of T cells in vivo and in vitro in the context of NDV. The results demonstrated that infection with lentogenic strain LaSota induced a phenotypic maturation of immature DCs (imDCs), which actually led to curtailed T cell responses. Upon infection, the phenotypic maturation of DCs was reflected by markedly enhanced MHC and costimulatory molecule expression and secretion of proinflammatory cytokines. Nevertheless, NDV-infected DCs produced the anti-inflammatory cytokine IL-10 and attenuated T cell proliferation, inducing Th2-biased responses. Therefore, our study reveals a novel understanding that DCs are phenotypically mature but dysfunctional in priming T cell responses during NDV infection.

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