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A trivalent enteric coronaviruses inactivated vaccine provides effective protection against PEDV, TGEV, and PDCoV

文献类型： 外文期刊

作者： Fan, Liyuan 1 ; Yi, Xin 1 ; Zhong, Chunyan 6 ; Yang, Chuangye 6 ; Niu, Ziyi 1 ; Xue, Xiaofeng 1 ; Wang, Wei 1 ; Guo, Rongli 1 ; Ma, Jiale 3 ; Zha, Yinhe 5 ; Shu, Jianhong 5 ; Li, Jizong 1 ; Li, Bin 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr, Nanjing 210014, Peoples R China

2.Jiangsu Univ, Inst Life Sci, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China

3.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China

4.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Peoples R China

5.Zhejiang Hongsheng Biotechnol CO LTD, Shaoxing 312000, Peoples R China

6.Southwest Guizhou Vocat & Tech Coll Nationalities, Biol Engn Dept, Xingyi 562400, Peoples R China

7.Minist Sci & Technol, Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base, Nanjing 210014, Peoples R China

关键词： Porcine epidemic diarrhea virus; Transmissible gastroenteritis virus; Porcine deltacoronavirus; Trivalent inactivated vaccine; Protection efficacy

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：2.7； 五年影响因子：2.9 ）

ISSN： 0378-1135

年卷期： 2025 年 308 卷

页码：

收录情况： SCI

摘要： Porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) are three major coronaviruses responsible for severe diarrhea and mortality in piglets. Coinfections of these pathogens are frequently present in clinical cases, which aggravate the clinical symptoms and cause substantial economic losses in the swine industry. Currently, no commercially available vaccine has broad-spectrum protective efficacy against all three viruses. In this study, we developed a trivalent inactivated vaccine targeting PEDV, TGEV, and PDCoV, to evaluate its immune protection, suckling piglets were intramuscular immunized with trivalent inactivated vaccine using prime-boost immunization. Neutralizing antibody assay showed that all vaccinated piglets achieved titers of 1:64 or higher at 7 day-post-boost immunization. The pigs were orally challenged with PEDV, TGEV, and PDCoV respectively. More severe and prolonged diarrhea, higher levels of viral shedding, substantial intestinal villus atrophy, and positive straining of viral antigens in ileum were detected in challenge control groups, while the trivalent inactivated vaccine groups exhibited significantly milder diarrhea symptom, lower levels of viral shedding, minor intestinal villi damage and minimal straining of viral antigens. These results demonstrated that the PEDV-TGEV-PDCoV trivalent inactivated vaccine provide effective protection in pigs against all three enteric coronaviruses.

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