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Combined detection of CA15-3, CEA, and SF in serum and tissue of canine mammary gland tumor patients

文献类型： 外文期刊

作者： Fan, Yuying 1 ; Ren, Xiaoli 2 ; Liu, Xuesong 3 ; Shi, Dongmei 2 ; Xu, Enshuang 1 ; Wang, Shuang 1 ; Liu, Yun 1 ;

作者机构： 1.Northeast Agr Univ, Dept Vet Clin, Coll Vet Med, Harbin 150000, Heilongjiang, Peoples R China

2.Henan Univ Anim Husb & Econ, Coll Vet Med, Zhengzhou 450046, Henan, Peoples R China

3.Heilongjiang Acad Agr Sci, Branch Anim Husb & Vet, Qiqihar 161000, Heilongjiang, Peoples R China

期刊名称：SCIENTIFIC REPORTS （ 影响因子：3.998； 五年影响因子：4.576 ）

ISSN： 2045-2322

年卷期： 2021 年 11 卷 1 期

页码：

收录情况： SCI

摘要： The purpose of this study is to evaluate the levels and clinical diagnosis value of CA15-3, CEA, and SF in canine mammary gland tumors (CMGTs). In this study, the levels of tissues/serum CA15-3, CEA, and SF in 178 CMGT patients or healthy dogs were determined by ELISA and qRT-PCR assay. CA15-3, CEA, and SF levels of the malignant tumor group were significantly higher than that of the benign tumor group and the healthy control group. In the malignant tumor group, CA15-3 held a sensitivity of 51.8%, a specificity of 93.9%, and an accuracy of 76.8%. The sensitivity, specificity, and accuracy of CEA were 44.6%, 84.1%, and 68.1% respectively. SF held a sensitivity of 62.5%, a specificity of 85.4%, and an accuracy of 76.1%. SF showed the highest sensitivity and CA15-3 showed the highest specificity. The sensitivity, specificity, and accuracy of the combined detection of the three biomarkers in malignant tumor groups were 80.4%, 78.0%, and 80.0%, respectively, therefore combined detection increased sensitivity and accuracy but decreased specificity. In conclusion, the combined detection of serum/tissue markers CA15-3, CEA, and SF may improve the detection sensitivity of CMGTs, providing reference value for clinical application.

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