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Synergistic effects of unripe raspberry extracts (Rubus chingii) and antibiotics against three bacteria

文献类型： 外文期刊

作者： Jiang, Huichuan 1 ; Yang, Jing 2 ; Fan, Yanling 2 ; Liu, Yongping 2 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Minist Agr & Rural Affairs, Key Lab Biol & Genet Resources Rubber Tree, Rubber Res Inst, Haikou, Hainan, Peoples R China

2.North Univ China, Sch Chem Engn & Technol, Taiyuan, Peoples R China

关键词： antibiotics; ellagic acid; natural antimicrobials; raspberry extracts; synergistic effects

期刊名称：FOOD SCIENCE AND TECHNOLOGY （ 影响因子：1.443； 五年影响因子：1.891 ）

ISSN： 0101-2061

年卷期： 2021 年 41 卷 2 期

页码：

收录情况： SCI

摘要： Dried unripe raspberries (Rubus chingii), a kind of Chinese herbal medicine, have been used for many years in China. They were prepared as unpurified raspberry extract (URE) by ethanol extraction, and purified raspberry extract (PRE) by macroporous resin. Synergistic effects between the URE (or the PRE) and ampicillin, erythromycin, tetracycline or streptomycin against Escherichia coli, Staphylococcus aureus and Salmonella enterica were carried out using checkerboard microdilution and time-kill curves, respectively. The results showed that all pairwise combinations revealed synergistic effects, with 0.10 <= fractional inhibitory concentration index <= 0.50 and more than 2 x log(10) reduction in colony-forming units/mL. In particular, the erythromycin concentration in the combinations was reduced to 1/50-1/100 of its dose alone while retaining its effectiveness against S. aureus and E. coli. The synergistic effects of raspberry extracts and four antibiotics against three bacteria were related to the abundance of polyphenols in the extracts, especially ellagic acid. The extracts may be a dietary supplement and/or natural antimicrobials.

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