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Toxicological and physiological effects of successive exposure to ochratoxin A at food regulatory limits

文献类型： 外文期刊

作者： Wei, Wei 1 ; Liu, Chong 2 ; Ke, Ping 2 ; Chen, Xiaoyun 1 ; Zhou, Ting 3 ; Xu, Junfeng 1 ; Zhou, Yu 4 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China

2.Second Mil Med Univ, Sch Pharm, Dept Pharmacol, Shanghai 200433, Peoples R China

3.Agr & Agri Food Canada, Guelph Res & Dev Ctr, Guelph, ON N1G 5C9, Canada

4.Anhui Agr Univ, Sch Tea & Food Sci Technol, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Peoples R China

关键词： Ochratoxin A; Regulatory limits; Toxicological impacts; Apoptosis

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：4.679； 五年影响因子：4.55 ）

ISSN： 0278-6915

年卷期： 2021 年 151 卷

页码：

收录情况： SCI

摘要： Ochratoxin A (OTA), a potent mycotoxin, is a common contaminant of agro-products, which seriously threatens food safety. The OTA regulatory limits vary from different countries/regions. However, little is known about the toxicological effects of successive exposure to regulatory levels of OTA. In this study, feedstuffs contaminated with 0.5-20 mu g kg(-1) OTA were evaluated in Sprague-Dawley (SD) rats. During the study, poisoning-associated behaviors, and significant differences of body weight and food intake, were not observed between OTA-treated rats and control group. However, the renal function indexes of blood urea nitrogen (BUN) and creatinine (CR) increased, and architecture destruction of glomeruli and tubuli was observed from the OTA-treated groups. The apoptosis study indicated that at a concentration of 20 mu g kg(-1), OTA modulated apoptosis in renal tissues via the Bcl-2/Bax pathway. The results of this study suggest that exposure to low doses of OTA successively at levels lower than the regulatory limits of certain countries could induce nephrotoxicity, and modulate apoptosis. Therefore, agencies pertaining to food safety should establish strict OTA regulatory limits for food and feedstuff.

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