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High Chromosomal Stability and Immortalized Totipotency Characterize Long-Term Tissue Cultures of Chinese Ginseng (Panax ginseng)

文献类型： 外文期刊

作者： Liu, Sitong 1 ; Zhao, Jing 2 ; Liu, Yutong 2 ; Li, Ning 2 ; Wang, Zhenhui 3 ; Wang, Xinfeng 4 ; Liu, Xiaodong 2 ; Jiang, 1 ;

作者机构： 1.Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China

2.Northeast Normal Univ, Key Lab Mol Epigenet, Minist Educ MOE, Changchun 130024, Peoples R China

3.Jilin Agr Univ, Dept Agron, Changchun 130118, Peoples R China

4.Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Biodivers Sci & Ecol Engn, Shanghai 200438, Peoples R China

5.Jilin Acad Agr Sci, Changchun 130118, Peoples R China

关键词： chromosomal stability; totipotency; tissue culture; ginseng; carcinogenesis; human health

期刊名称：GENES （ 影响因子：3.759； 五年影响因子：3.822 ）

ISSN：

年卷期： 2021 年 12 卷 4 期

页码：

收录情况： SCI

摘要： Chinese ginseng (Panax ginseng C. A. Meyer) is a highly cherished traditional Chinese medicine, with several confirmed medical effects and many more asserted health-boosting functions. Somatic chromosomal instability (CIN) is a hallmark of many types of human cancers and also related to other pathogenic conditions such as miscarriages and intellectual disabilities, hence, the study of this phenomenon is of wide scientific and translational medical significance. CIN also ubiquitously occurs in cultured plant cells, and is implicated as a major cause of the rapid decline/loss of totipotency with culture duration, which represents a major hindrance to the application of transgenic technologies in crop improvement. Here, we report two salient features of long-term cultured callus cells of ginseng, i.e., high chromosomal stability and virtually immortalized totipotency. Specifically, we document that our callus of ginseng, which has been subcultured for 12 consecutive years, remained highly stable at the chromosomal level and showed little decline in totipotency. We show that these remarkable features of cultured ginseng cells are likely relevant to the robust homeostasis of the transcriptional expression of specific genes (i.e., genes related to tissue totipotency and chromosomal stability) implicated in the manifestation of these two complex phenotypes. To our knowledge, these two properties of ginseng have not been observed in any animals (with respect to somatic chromosomal stability) and other plants. We posit that further exploration of the molecular mechanisms underlying these unique properties of ginseng, especially somatic chromosomal stability in protracted culture duration, may provide novel clues to the mechanistic understanding of the occurrence of CIN in human disease.

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