Proteomics analysis of the hypothalamus of high-fat diet fed mice after Lactiplantibacillus plantarum Y44 administration
文献类型： 外文期刊
作者： Wu, Xiaomeng 1 ; Wang, Yajuan 1 ; Du, Xinyu 1 ; Liu, Yujun 1 ; Gao, Yuan 2 ; Tuo, Yanfeng 1 ; Mu, Guangqing 1 ;
作者机构： 1.Dalian Polytech Univ, Sch Food Sci & Technol, Dalian 116000, Liaoning, Peoples R China
2.Zhejiang Acad Agr Sci, Food Sci Inst, Hangzhou 310021, Peoples R China
关键词： High-fat diet; Lactiplantibacillus plantarum; Proteomic
期刊名称：FOOD BIOSCIENCE （ 影响因子：5.318； 五年影响因子：5.846 ）
ISSN： 2212-4292
年卷期： 2022 年 47 卷
页码：
收录情况： SCI
摘要： Probiotics could regulate human health via changing gut microbiota. Our previous studies found that Lacti-plantibacillus plantarum Y44 (L. plantarum Y44) was shown to reverse obesity-related symptoms of high-fat diet fed mice by influencing gut microbiota, which ameliorated lipid metabolism disorders and intestinal inflam-mation. In this study, the effects of L. plantarum Y44 on high-fat fed mice and the involved mechanisms were investigated through hypothalamus proteomics analysis, which revealed 22 downregulated and 21 upregulated proteins. Differentially expressed proteins between L. plantarum Y44 intervention group and high-fat fed group in hypothalamus of mice involved in metabolic pathways were concentrated in endocrine regulation of carbohy-drate, amino acid and energy generation pathways. The hypothalamus proteomics results about the influences on most of differentially expressed proteins of L. plantarum Y44 administering high-fat fed mice has been verified. Therefore, L. plantarum Y44 would be a potential functional strain for the amelioration of high-fat diet associated health problems.
- 相关文献
作者其他论文 更多>>
-
Simulated gastrointestinal digestion of walnut protein yields anti-inflammatory peptides
作者：Xia, Wei;Fang, Xiangjun;Liu, Ruiling;Wu, Weijie;Gao, Haiyan;Yang, Hailong;Jin, Long;Deng, Yangyong;Gao, Junlong;Gao, Yuan;Wang, Li-Shu;Wang, Li-Shu
关键词：Walnut protein; Simulated digestion; Metabolic changes; Molecular docking; Inflammation; Cell experimental verification
-
Advances of stable isotope technology in food safety analysis and nutrient metabolism research
作者：Xia, Wei;Fang, Xiangjun;Gao, Yuan;Wu, Weijie;Han, Yanchao;Liu, Ruiling;Chen, Hangjun;Gao, Haiyan;Yang, Hailong
关键词：Stable isotope dilution analysis; Stable isotope tracing; Food safety; Nutrient metabolism; Human health
-
Hepatoprotective effect of water bamboo shoot (Zizania latifolia) extracts against acute alcoholic liver injury in a mice model and screening of bioactive phytochemicals
作者：Gao, Yuan;Zong, Zihao;Xia, Wei;Fang, Xiangjun;Liu, Ruiling;Wu, Weijie;Mu, Honglei;Han, Yanchao;Xiao, Shangyue;Gao, Haiyan;Chen, Hangjun;Xiao, Shangyue;Gao, Yuan
关键词：alcoholic liver injury; bioactive phytochemicals; NF-kappa B pathway; proinflammatory cytokines; water bamboo shoot
-
The mitigative effect of lotus root (Nelumbo nucifera Gaertn) extract on acute alcoholism through activation of alcohol catabolic enzyme, reduction of oxidative stress, and protection of liver function
作者：Yang, Zihan;Gao, Yuan;Wu, Weijie;Mu, Honglei;Liu, Ruiling;Fang, Xiangjun;Gao, Haiyan;Chen, Hangjun;Yang, Zihan;Gao, Yuan;Wu, Weijie;Mu, Honglei;Liu, Ruiling;Fang, Xiangjun;Gao, Haiyan;Chen, Hangjun;Yang, Zihan;Gao, Yuan;Wu, Weijie;Mu, Honglei;Liu, Ruiling;Fang, Xiangjun;Gao, Haiyan;Chen, Hangjun;Yang, Zihan;Gao, Yuan;Wu, Weijie;Mu, Honglei;Liu, Ruiling;Fang, Xiangjun;Gao, Haiyan;Chen, Hangjun;Yang, Zihan;Gao, Yuan;Wu, Weijie;Mu, Honglei;Liu, Ruiling;Fang, Xiangjun;Gao, Haiyan;Chen, Hangjun
关键词：lotus root; acute alcoholism; antioxidant activity; active substance; acetaldehyde dehydrogenase
-
Ameliorating effects of water bamboo shoot (Zizania latifolia) on acute alcoholism in a mice model and its chemical composition
作者：Gao, Yuan;Chen, Hangjun;Liu, Ruiling;Wu, Weijie;Mu, Honglei;Han, Yanchao;Gao, Haiyan;Yang, Hailong
关键词：Water bamboo shoot; Acute alcoholism; Antioxidant activity; Active substance; Alcohol dehydrogenase
-
Impact of thermal processing on dietary flavonoids
作者：Gao, Yuan;Xia, Wei;Wu, Weijie;Chen, Hangjun;Fang, Xiangjun;Mu, Honglei;Gao, Haiyan;Shao, Ping;Xiao, Jianbo
关键词：
-
Lactobacillus plantarum Y44 alleviates oxidative stress by regulating gut microbiota and colonic barrier function in Balb/C mice with subcutaneous d-galactose injection
作者：Gao, Yuan;Liu, Yujun;Ma, Fenglian;Sun, Mengying;Song, Yinglong;Xu, Dongxue;Mu, Guangqing;Tuo, Yanfeng;Gao, Yuan;Ma, Fenglian;Sun, Mengying;Song, Yinglong;Mu, Guangqing;Tuo, Yanfeng
关键词：
