文献类型： 外文期刊
作者： Yang, Chenbo 1 ; Tong, Ling 4 ; Xue, Jing 1 ;
作者机构： 1.Chinese Acad Med Sci, Inst Lab Anim Sci, NHC Key Lab Human Dis Comparat Med, State Key Lab Resp Hlth & Multimorbid,Beijing Key, Beijing 100021, Peoples R China
2.Peking Union Med Coll, Beijing 100021, Peoples R China
3.Chinese Acad Med Sci, Ctr AIDS Res, Beijing 100730, Peoples R China
4.Jiangsu Acad Agr Sci, Inst Vet Immunol & Engn, Nanjing 210014, Peoples R China
关键词： HIV-1 latency; Reservoir; Viral persistence; CRISPR screening; Viral eradication
期刊名称：JOURNAL OF VIRUS ERADICATION （ 影响因子：2.0； 五年影响因子：2.5 ）
ISSN： 2055-6640
年卷期： 2025 年 11 卷 2 期
页码：
收录情况： SCI
摘要： Antiretroviral therapy (ART) has transformed HIV from a fatal disease into manageable circumstance. However, the HIV reservoirs remain a main barrier to complete cure. This review emphasized when, where and how the latency is established, with focus on various host factors and viral proteins. We highlight the importance of Tat and Rev in facilitating the export and stability of HIV latency. We discuss how transcription factors such as NF kappa B, NFAT, and Sp1 regulate HIV gene expression during T cell activation, while other factors like MRTFB, BACH2, FOXO1, HMGB1, SAMHD1, APOBEC3, TRIM5, Wnt/beta-catenin and LEDGF/p75 also contribute to the persistence of reservoirs. Recent studies have also identified novel restriction and immune regulatory factors such as, LAPTM5, KRT72, and CARD8, directly or indirectly influencing HIV 1 latency. The advancements in CRISPR screening technology have also identified novel host factors, such as FBXO34, FTSJ3, TMEM178A, NICN1, PEBP1, ZNF304 and ORC1, that are associated with HIV-1 latency. These findings underscore the multifaceted nature of viral latency and ongoing need for research to develop effective strategies for viral eradication.
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