Development and evaluation of a novelty single-step cleanup followed by HPLC-QTRAP-MS/MS for rapid analysis of tricaine, tetracaine, and bupivacaine in fish samples
文献类型： 外文期刊
作者： Mu, Shuhe 1 ; Wang, Chunyu 1 ; Liu, Huan 1 ; Han, Gang 1 ; Wu, Lidong 1 ; Li, Jincheng 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Beijing 100141, Peoples R China
2.Minist Agr, Key Lab Control Qual & Safety Aquat Prod, Beijing 100141, Peoples R China
3.Chinese Acad Fishery Sci, Hainan Innovat Res Inst, Haikou, Hainan, Peoples R China
4.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai, Peoples R China
关键词： cheap analytical filtration syringe cleanup column; determination; fish; HPLC-QTRAP-MS/MS; QuEChERS
期刊名称：BIOMEDICAL CHROMATOGRAPHY （ 影响因子：1.902； 五年影响因子：1.809 ）
ISSN： 0269-3879
年卷期： 2021 年 35 卷 10 期
页码：
收录情况： SCI
摘要： A novelty single-step cleanup method combined with HPLC coupled with triple quadrupole-linear ion trap MS/MS (HPLC-QTRAP-MS/MS) was developed for the analysis of tricaine, tetracaine, and bupivacaine in fish tissue. The target analytes were extracted using acetonitrile based on the modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) method under ultrasound irradiation. A cheap analytical filtration syringe (CAFS) cleanup column for single-step purification was proposed first; 300 mg of primary/secondary amino was proposed as the optimum purification sorbent; 1 mL of acetonitrile extract was transferred into a CAFS cleanup column and purified for analysis using HPLC-QTRAP-MS/MS. The limits of detection and the limits of quantification were 2.0 and 5.0 mu g kg(-1), respectively. The recoveries were in the range of 88.73-108.72%. Inter-day and intra-day relative standard deviations were lower than 15% for all analytes. The developed method has been applied to measure real samples obtained from the local market.
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