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Single-cell RNA sequencing in skeletal muscle developmental biology

文献类型： 外文期刊

作者： Cai, Cuicui 1 ; Yue, Yuan 3 ; Yue, Binglin 1 ;

作者机构： 1.Southwest Minzu Univ, Sichuan Prov & Minist Educ, Key Lab Qinghai Tibetan Plateau Anim Genet Resourc, Chengdu 610225, Peoples R China

2.Ningxia Acad Agr & Forestry Sci, Guyuan Branch, Guyuan, Peoples R China

3.Hebei Univ Chinese Med, Dept Pathobiol & Immunol, Shijiazhuang 050200, Peoples R China

关键词： ScRNA-seq; Skeletal muscle; Cellular heterogeneity; Pseudotime patterns; Cell-cell communication

期刊名称：BIOMEDICINE & PHARMACOTHERAPY （ 影响因子：7.5； 五年影响因子：6.8 ）

ISSN： 0753-3322

年卷期： 2023 年 162 卷

页码：

收录情况： SCI

摘要： Skeletal muscle is the most extensive tissue in mammals, and they perform several functions; it is derived from paraxial mesodermal somites and undergoes hyperplasia and hypertrophy to form multinucleated, contractile, and functional muscle fibers. Skeletal muscle is a complex heterogeneous tissue composed of various cell types that establish communication strategies to exchange biological information; therefore, characterizing the cellular heterogeneity and transcriptional signatures of skeletal muscle is central to understanding its ontogeny's details. Studies of skeletal myogenesis have focused primarily on myogenic cells' proliferation, differentiation, migration, and fusion and ignored the intricate network of cells with specific biological functions. The rapid development of single-cell sequencing technology has recently enabled the exploration of skeletal muscle cell types and molecular events during development. This review summarizes the progress in single-cell RNA sequencing and its applications in skeletal myogenesis, which will provide insights into skeletal muscle pathophysiology.

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