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The Association of the Copy Number Variation of the MLLT10 Gene with Growth Traits of Chinese Cattle

文献类型： 外文期刊

作者： Yang, Peng 1 ; Zhang, Zijing 2 ; Xu, Jiawei 1 ; Qu, Kaixing 3 ; Lyv, Shijie 2 ; Wang, Xianwei 4 ; Cai, Cuicui 5 ; Li, Zhi 1 ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China

2.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou 45002, Peoples R China

3.Yunnan Acad Grassland Anim Sci, Kunming 650212, Yunnan, Peoples R China

4.Henan Prov Anim Husb Gen Stn, Zhengzhou 450008, Peoples R China

5.Ningxia Acad Agr & Forestry Sci, Guyuan Branch, Guyuan 756000, Peoples R China

关键词： copy number variations (CNVs); MLLT10 gene; growth traits; association analysis

期刊名称：ANIMALS （ 影响因子：2.752； 五年影响因子：2.942 ）

ISSN： 2076-2615

年卷期： 2020 年 10 卷 2 期

页码：

收录情况： SCI

摘要： Simple Summary Copy number variation is a common genetic polymorphism, mainly represented by submicroscopic levels of deletion and duplication, caused by rearrangement of the genome. It is well-known that the copy number variation of a gene is associated with growth traits of livestock. In this study, we detected the correlation between the copy number variation of the the MLLT10 gene and the growth traits of Chinese yellow cattle. We found that the copy number variation of the MLLT10 gene has a significant influence on hip width, rump length, hucklebone width, and cannon bone circumference of some Chinese yellow cattle breeds. The results provide preliminary suggestions for Chinese yellow cattle breeding and new insights about the future of copy number variation (CNV) as a new promising molecular marker in animal breeding. Copy number variation is a part of genomic structural variation and has caused widespread concern. According to the results of high-throughput screening of the MLLT10 gene, we found that the copy number variation region of the MLLT10 gene was correlated with bovine growth traits. We aimed to detect the MLLT10 gene copy number variation and provide materials for the Chinese yellow cattle breed. In this study, the SPSS software was used to analyze the correlation among the copy number type of six different cattle breeds (i.e., Qinchuan, Xianan, Jiaxian, Yanbian, Sinan, Yunling) and the corresponding growth traits. The results showed the following: In Qinchuan cattle, the copy number duplication type was greater than the deletion and normal types; in Xianan cattle, the copy number duplication and normal types were less as compared with the deletion type; and in Yunling cattle, the frequency of the duplication type was dominant among the three types of copy number variants. The correlation analysis result showed that there is a significant correlation between the copy number variation (CNV) of the MLLT10 gene and the growth traits of three cattle breeds. Furthermore, correlation analysis showed that MLLT10 CNV had positive effects on growth traits such as hip width, rump length, hucklebone width, and cannon bone circumference (p < 0.05). This study provides a basis for the molecular-assisted marker breeding of cattle and contributes to the breeding of cattle.

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