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Zeaxanthin Dipalmitate-Enriched Emulsion Stabilized with Whey Protein Isolate-Gum Arabic Maillard Conjugate Improves Gut Microbiota and Inflammation of Colitis Mice

文献类型: 外文期刊

作者: Kan, Xuhui 1 ; Zhou, Wangting 1 ; Xu, Weiqi 1 ; Dai, Zhuqing 2 ; Yan, Yamei 3 ; Mi, Jia 3 ; Sun, Yi 1 ; Zeng, Xiaoxiong 1 ; Cao, Youlong 3 ; Lu, Lu 3 ;

作者机构: 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Peoples R China

3.Ningxia Acad Agr & Forestry Sci, Inst Wolfberry Engn & Technol, Yinchuan 750004, Ningxia, Peoples R China

关键词: Lycium barbarum; zeaxanthin dipalmitate; protein-polysaccharide conjugate; gut microbiota; colitis

期刊名称:FOODS ( 影响因子:5.561; 五年影响因子:5.94 )

ISSN:

年卷期: 2022 年 11 卷 22 期

页码:

收录情况: SCI

摘要: In the present study, protein-polysaccharide Maillard conjugates were used as novel emulsifiers and bioactive carriers. Effects and potential mechanisms of zeaxanthin dipalmitate (ZD)-enriched emulsion stabilized with whey protein isolate (WPI)-gum Arabic (GA) conjugate (WPI-GA-ZD) and ZD-free emulsion (WPI-GA) on gut microbiota and inflammation were investigated using a model of dextran sulfate sodium (DSS)-induced colitis in mice. As a result, supplementation with WPI-GA and WPI-GA-ZD improved the serum physiological and biochemical indicators, decreased the expression of pro-inflammatory cytokines and related mRNA, as well as increased the tight junction proteins to a certain extent. 16S rDNA sequencing analyses showed that supplementation with WPI-GA and WPI-GA-ZD presented differential modulation of gut microbiota and played regulatory roles in different metabolic pathways to promote health. Compared with WPI-GA, the relative abundances of Akkermansia, Lactobacillus and Clostridium_IV genera were enriched by the intervention of WPI-GA-ZD. Overall, the designed carotenoid-enriched emulsion stabilized with protein-polysaccharide conjugates showed potential roles in promoting health.

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