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Prudent Use of Tylosin for Treatment of Mycoplasma gallisepticum Based on Its Clinical Breakpoint and Lung Microbiota Shift

文献类型： 外文期刊

作者： Huang, Anxiong 1 ; Wang, Shuge 4 ; Guo, Jinli 1 ; Gu, Yufeng 1 ; Li, Jun 5 ; Huang, Lingli 1 ; Wang, Xu 1 ; Tao, Yanfei 1 ;

作者机构： 1.Natl Reference Lab Vet Drug Residues HZAU, Wuhan, Peoples R China

2.MAO Key Lab Detect Vet Drug Residues, Wuhan, Peoples R China

3.Huazhong Agr Univ, MOA Lab Risk Assessment Qual & Safety Livestock &, Wuhan, Peoples R China

4.China Agr Univ, Coll Vet Med, Natl Ctr Vet Drug Safety Evaluat, Beijing, Peoples R China

5.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Nanjing, Peoples R China

关键词： Mycoplasma gallisepticum; tylosin; dosage regimen; clinical breakpoint; lung microbiota

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）

ISSN：

年卷期： 2021 年 12 卷

页码：

收录情况： SCI

摘要： The aim of this study was to explore the prudent use of tylosin for the treatment of chronic respiratory infectious diseases in chickens caused by Mycoplasma gallisepticum (MG) based on its clinical breakpoint (CBP) and its effect on lung microbiota. The CBP was established based on the wild-type/epidemiological cutoff value (COWT/ECV), pharmacokinetics-pharmacodynamics (PK-PD) cutoff value (COPD), and clinical cutoff value (COCL) of tylosin against MG. The minimum inhibitory concentration (MIC) of tylosin against 111 MG isolates was analyzed and the COWT was 2 mu g/ml. M17 with MIC of 2 mu g/ml was selected as a representative strain for the PK-PD study. The COPD of tylosin against MG was 1 mu g/ml. The dosage regimen formulated by the PK-PD study was 3 days administration of tylosin at a dose of 45.88 mg/kg b.w. with a 24-h interval. Five different MIC MGs were selected for clinical trial, and the COCL of tylosin against MG was 0.5 mu g/ml. According to the CLSI decision tree, the CBP of tylosin against MG was set up as 2 mu g/ml. The effect of tylosin on lung microbiota of MG-infected chickens was analyzed by 16S rRNA gene sequencing. Significant change of the lung microbiota was observed in the infection group and treatment group based on the principal coordinate analysis and the Venn diagrams of the core and unique OTU. The phyla Firmicutes and Proteobacteria showed difference after MG infection and treatment. This study established the CBP of tylosin against MG. It also provided scientific data for the prudent use of tylosin based on the evaluation of MG infection and tylosin treatment on the lung microbiota.

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