文献类型： 外文期刊
作者： Yan, Yunxiang 1 ; Li, Ye 3 ; Li, Hong 1 ; Ma, Xiang 1 ; Tang, Yanqiong 1 ; Yi, Kexian 3 ; Lin, Xiangmin 4 ; Li, Juanjuan 1 ; Liu, Zhu 1 ;
作者机构： 1.Hainan Univ, Sch Life Sci, Haikou 570228, Peoples R China
2.Hainan Univ, 1 Hlth Inst, Haikou 570228, Peoples R China
3.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Haikou 571101, Peoples R China
4.Fujian Agr & Forestry Univ, Sch Life Sci, Fujian Prov Key Lab Agroecol Proc & Safety Monitor, Fuzhou 350002, Peoples R China
关键词： drug-resistant bacteria; zeolitic imidazolate framework; SmpB protein; biofilm; cell membrane
期刊名称：ACS INFECTIOUS DISEASES （ 影响因子：5.3； 五年影响因子：5.1 ）
ISSN： 2373-8227
年卷期： 2023 年
页码：
收录情况： SCI
摘要： The horizontal transfer of drug-resistant genes and the formation of biofilm barriers have threatened the therapeutic efficacy of conventional antibiotic drugs. Development of nonantibiotic agents with high delivery efficiency through bacterial biofilms is urgently required. A pyrithione (PT)-loading zeolitic imidazolate framework (ZIF-8@PT) is synthesized to destroy biofilms and improve the sensitivity of bacteria to PT. ZIF-8@PT can target and destroy the biofilm as well as the cell membrane, promoting the intracellular delivery of PT and possibly its interaction with SmpB, a protein that could regulate the drug resistance of bacteria. ZIF-8@PT effectively suppresses abdominal infections induced by multiresistant Aeromonas veronii C4 in rodent models without systemic toxicity. ZIF-8@PT promises wide applications in treating infections caused by multidrug-resistant bacteria through a dual mechanism of action.
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