您好，欢迎访问江苏省农业科学院 机构知识库！
江苏省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Reverse Genetics Systems for Emerging and Re-Emerging Swine Coronaviruses and Applications

文献类型： 外文期刊

作者： Jiang, Hui 1 ; Wang, Ting 1 ; Kong, Lingbao 1 ; Li, Bin 5 ; Peng, Qi 1 ;

作者机构： 1.Jiangxi Agr Univ, Nanchang Key Lab Anim Virus & Genet Engn, Nanchang 330045, Peoples R China

2.Jiangxi Agr Univ, Inst Pathogen Microorganism, Nanchang 330045, Peoples R China

3.Chinese Acad Agr Sci, Dept Avian Infect Dis, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China

4.Jiangxi Agr Univ, Coll Biosci & Engn, Nanchang 330045, Peoples R China

5.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr, Nanjing 210014, Peoples R China

关键词： emerging and re-emerging swine coronaviruses; reverse genetics system; pathogenesis; vaccine development; antiviral drugs; cell and tissue tropism

期刊名称：VIRUSES-BASEL （ 影响因子：4.7； 五年影响因子：4.8 ）

ISSN：

年卷期： 2023 年 15 卷 10 期

页码：

收录情况： SCI

摘要： Emerging and re-emerging swine coronaviruses (CoVs), including porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and swine acute diarrhea syndrome-CoV (SADS-CoV), cause severe diarrhea in neonatal piglets, and CoV infection is associated with significant economic losses for the swine industry worldwide. Reverse genetics systems realize the manipulation of RNA virus genome and facilitate the development of new vaccines. Thus far, five reverse genetics approaches have been successfully applied to engineer the swine CoV genome: targeted RNA recombination, in vitro ligation, bacterial artificial chromosome-based ligation, vaccinia virus -based recombination, and yeast-based method. This review summarizes the advantages and limitations of these approaches; it also discusses the latest research progress in terms of their use for virus-related pathogenesis elucidation, vaccine candidate development, antiviral drug screening, and virus replication mechanism determination.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：江苏省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台